Detail projektu

Predikce ruptury výdutě břišní aorty na základě výpočtového modelování

Období řešení: 01.02.2013 — 31.12.2015

Zdroje financování

Grantová agentura České republiky - Standardní projekty

- plně financující (2013-02-01 - 2015-12-31)

O projektu

Projekt je zaměřen na zlepšení popisu mechanických vlastností tkání v individuálních výpočtových modelech aneurysmatu abdominální aorty (AAA) pacienta používaných k predikci ruptury. Experimentální část projektu se kromě měření mechanických vlastností intraluminálního trombu (ILT) bude věnovat zkouškám stěny AAA ve dvouosé napjatosti (do 3 hod. po odebrání) a histologickému vyhodnocování orientace kolagenních vláken ve stěně. Využití získaných poznatků k deformačně-napěťové analýze AAA zahrnuje použití nelineárního poroelastického konstitutivního modelu ILT, včetně závislosti jeho parametrů na tloušťce a deformaci ILT, dále vícevrstvé konstitutivní modely stěny AAA, zohlednění jeho nezatížené geometrie a zbytkové napjatosti, zahrnutí koncentrace napětí na odbočujících tepnách a zhodnocení významu orientace kolagenních vláken. Pro predikci porušení AAA budou analýzy využívat rozložení indexu rizika porušení, což oproti metodě maximálních napětí umožňuje lépe popsat místo pravděpodobného porušení se zahrnutím lokálního snižování pevnosti stěny nebo její směrové závislosti.

Popis anglicky
The project aims at improvement of description of mechanical properties of tissues in patient-specific computational models of abdominal aortic aneurysm (AAA) used in rupture prediction. The project deals with experimental measurements of mechanical properties of intraluminal thrombus (ILT), testing of the AAA wall under biaxial stress conditions and histological evaluation of orientation of collagen fibres in the wall. Application of the acquired data in AAA stress-strain analyses comprehends non-linear poroelastic constitutive model of ILT, incl. dependence of its parameters on the thickness and deformation of the ILT, multilayer models of the AAA wall, its unloaded geometry and residual stresses, accounting for stress concentration on the branch arteries and evaluation of the orientation of collagen fibres. For prediction of AAA rupture the rupture risk index will be used, which enables one to describe better the probable rupture location than maximum von Mises stress by including the local reduction of the ultimate stress or its direction dependency.

Klíčová slova
výdut aorty, hyperelastický materiál, intraluminální trombus, index rizika ruptury, kolagenní vlákno

Klíčová slova anglicky
aortic; aneurysm; hyperelastic; material; intraluminal; thrombus; rupture; risk; index; collagen; fibre

Označení

GA13-16304S

Originální jazyk

čeština

Řešitelé

Burša Jiří, prof. Ing., Ph.D. - hlavní řešitel

Útvary

Ústav mechaniky těles, mechatroniky a biomechaniky
- příjemce (01.02.2013 - 31.12.2015)

Výsledky

FEDOROVA, S. Computational modelling of fibre-reinforced hyperelastic solids with fibre bending stiffness. Brno: 2013. p. 61-61. ISBN: 978-80-214-4739-4.
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POLZER, S.; GASSER, T.; VLACHOVSKÝ, R.; KUBÍČEK, L.; LAMBERT, L.; MAN, V.; NOVÁK, K.; SLAŽANSKÝ, M.; BURŠA, J.; STAFFA, R. Biomechanical indices are more sensitive than diameter in predicting rupture of asymptomatic abdominal aortic aneurysms. JOURNAL OF VASCULAR SURGERY, 2020, vol. 71, no. 2, p. 617 (+ p.)ISSN: 0741-5214.
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SKÁCEL, P.; BURŠA, J. Numerical implementation of constitutive model for arterial layers with distributed collagen fibre orientations. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, 2013, vol. 2014, no. 01, p. 1-13. ISSN: 1025-5842.
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BURŠA, J.; BANSOD, Y. Design and applications of prestressed tensegrity structures. In Engineering Mechanics 2014, Book of full texts. Svratka: Czech Society for Mechanics, 2014. p. 30-33. ISBN: 978-80-214-4871-1.
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LASOTA, T. FE model of fibre composite based on large strain Cosserat elasticity. žádná. žádná. Saarbrucken,Německo: Scholar's Press, 2014. 150 p. ISBN: 978-3-639-66175-0.
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SKÁCEL, P.; BURŠA, J. Comparison of constitutive models of arterial layers with distributed collagen fibre orientations. Acta of Bioengineering and Biomechanics, 2014, vol. 2014, no. 03, p. 47-58. ISSN: 1509-409X.
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POLZER, S.; GASSER, T.; NOVÁK, K.; MAN, V.; TICHÝ, M.; SKÁCEL, P.; BURŠA, J. Structure-based constitutive model can accurately predicts planar biaxial properties of arotic wall tissue. Acta Biomaterialia, 2015, vol. 14, no. 1, p. 133-145. ISSN: 1742-7061.
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NOVÁK, K.; POLZER, S.; TICHÝ,M.; BURŠA, J. Automatic Evaluation of Collagen Fiber Directions from Polarized Light Microscopy Images. MICROSCOPY AND MICROANALYSIS, 2015, vol. 21, no. 4, p. 863-875. ISSN: 1431-9276.
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FEDOROVA, S. Computational Modeling of Fiber Composites with Thick Fibers as Homogeneous Structures with Use of Couple Stress Theory. In Design and Analysis of Reinforced Fiber Composites. Pedro V. Marcal, Nobuki Yamagata. 2015. p. 25-47. ISBN: 978-3-319-20007-1.
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SLAŽANSKÝ, M.; POLZER, S.; BURŠA, J. Finite element analyses of biaxial tension testing with different ways of specimen clamping. 2014.
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SLAŽANSKÝ, M.; POLZER, S.; BURŠA, J. Finite element based parametric study of inaccuracies in mechanical testing of soft tissue. 2015.
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MAN, V.; NOVÁK, K.; POLZER, S.; BURŠA, J. Can Laplace law replace more sophisticated analyses of aortic aneurysms?. Špičák: 2014.
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MAN, V.; NOVÁK, K.; POLZER, S.; BURŠA, J. Applicability of simplified models of abdominal aortic aneurysms. Barcelona: 2014.
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POLZER, S.; BURŠA, J.; MAN, V. ALGORITHM FOR INTRODUCING RESIDUAL STRESSES INTO FINITE ELEMENT MODELS OF ANEURYSMS. Prague: 2015.
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MAN, V.; SKÁCEL, P.; POLZER, S.; ŠEVČÍK, V.; BURŠA, J. PRACTICAL ASPECT OF BIAXIAL TESTING OF VASCULAR TISSUE. Prague: 2015.
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SLAŽANSKÝ, M.; POLZER, S.; BURŠA, J. ANALYSIS OF ACCURACY OF BIAXIAL TESTS BASED ON COMPUTATIONAL SIMULATIONS. In CMBE15 4th International Conference on Computational & Mathematical Biomedical Engineering. Swansea, United-Kingdom: CMBE, Zeta Computational Resources Ltd.Swansea, United-Kingdom, 2015. p. 168-171. ISBN: 978-0-9562914-3-1.
Detail

BANSOD, Y.; BURŠA, J. Continuum-based modeling approaches to cell mechanics. World Academy of Science, Engineering and Technology, 2015, vol. 2, no. 9, p. 1202-1213. ISSN: 1307-6892.
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NOVÁK, K.; POLZER, S.; TICHÝ, M.; BURŠA, J. Automatic evaluation of collagen fibre directions from polarized light microscopy images. 2014. p. 1-2.
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NOVÁK, K.; POLZER, S. Automated algorithm evaluating orientation of structures from polarized light microscopy images. 2015. p. 1 (1 s.).
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BURŠA, J.; BANSOD, Y. Models of Living Cells on the Basis of Tensegrity Structures. In 6th World Conference on Structural Contral and Monitoring. Barcelona, Spain.: 6th World Conference on Structural Control and Monitoring (6WCSCM)., 2014. p. 140-146. ISBN: 978-84-942844-5-8.
Detail

BANSOD, Y.; BURŠA, J. Tensigrity Principle Based Computational Model of Cytoskeleton. In 6th World Conference on Structural Control and Monitoring (6WCSCM). Barcelona, Spain: 6th World Conference on Structural Control and Monitoring (6WCSCM)., 2014. p. 3317-3326. ISBN: 978-84-942844-5-8.
Detail

POLZER, S.; GASSER, T. Biomechanical rupture risk assessment of abdominal aortic aneurysms based on a novel probabilistic rupture risk index. Journal of the Royal Society Interface, 2015, vol. 113, no. 12, p. 1-11. ISSN: 1742-5689.
Detail

Luboš Kubíčeka, Robert Staffa, Robert Vlachovský , Stanislav Polzer, Peter Kružliak. Incidence of small abdominal aortic aneurysms rupture, impact of comorbidities and our experience with rupture risk prediction based on wall stress assessment. Cor at Vasa, 2015, vol. 57, no. 2, p. 127-132. ISSN: 0010-8650.
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SKÁCEL, P.; BURŠA, J. Poisson's ratio of arterial wall – inconsistency of constitutive models with experimental data. Journal of the mechanical behavior of biomedical materials, 2016, vol. 54, no. 1, p. 316-327. ISSN: 1751-6161.
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SLAŽANSKÝ, M.; POLZER, S.; BURŠA, J. Analysis of Accuracy of Biaxial Tests Based on their Computational Simulations. Strain, 2016, vol. 52, no. 5, p. 424-435. ISSN: 1475-1305.
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FEDOROVA, S.; BURŠA, J. Application of polar elasticity to the problem of pure bending of a thick plate. In ECCOMAS Congress 2016 - Proceedings of the 7th European Congress on Computational Methods in Applied Sciences and Engineering. Crete, Greece: National Technical University of Athens, 2016. p. 2162-2171. ISBN: 9786188284401.
Detail

Stanislav Polzer, Kamil Novák, Jiří Burša. Feasibility of Incorporating Blood Pressure Distribution into Rupture Risk Assesment of Abdominal Aortic Aneurysm. ESB 2016, Lyon: 2016. p. 1 (1 s.).
Detail

NOVÁK, K.; POLZER, S.; KŘIVKA, T.; VLACHOVSKÝ, R.; STAFFA, R.; KUBÍČEK, L.; LAMBERT, L.; BURŠA, J. Correlation between transversal and orthogonal maximal diameters of abdominal aortic aneurysms and alternative rupture risk predictors. COMPUTERS IN BIOLOGY AND MEDICINE, 2017, vol. 83, no. 3, p. 151-156. ISSN: 0010-4825.
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POLZER, S.; GASSER, T.; FORSELL, C.; DRUCKMÜLLEROVÁ, H.; TICHÝ, M.; STAFFA, R.; VLACHOVSKÝ, R.; BURŠA, J. Automatic Identification and Validation of Planar Collagen Organization in the Aorta Wall with Application to Abdominal Aortic Aneurysm. MICROSCOPY AND MICROANALYSIS, 2013, vol. 19, no. 6, p. 1395-1404. ISSN: 1431-9276.
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Odpovědnost: Burša Jiří, prof. Ing., Ph.D.