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VOJTOVÁ, L. JANČÁŘ, J. JUHÁSOVÁ, J. NEČAS, A. CRHA, M. PROKS, P. PLÁNKA, L.
Originální název
Regeneration of articular cartilage and growth plate by 3D resorbable biopolymer composites seeded with mesenchymal stem cells and chondrocytes
Typ
abstrakt
Jazyk
angličtina
Originální abstrakt
Mini invasive method targeted replacement of tissue defects of articular cartilage and growth plate have been proposed based on our experience in the treatment of bone defects in miniature pigs using new biopolymer composites seeded with Mesenchymal Stem Cells (MSCs). To study the regeneration of articular cartilage and growth plate, scaffold with self-supporting three-dimensional structures of collagen and chitosan fibers allowing both hydrodynamic casting MSCs and chondrocytes, and good handling, was chosen. These biodegradable scaffolds with seeded cells have successfully undergone preclinical testing on rabbits and minipigs, which were implanted at the site of damage cartilage (knee articular or distal epiphysis). The scaffold initiates tissue regeneration and resorbs in the body with controlled manner.
Klíčová slova
collagen, scaffold, chitosan, cartilage, growth plate, regeneration
Autoři
VOJTOVÁ, L.; JANČÁŘ, J.; JUHÁSOVÁ, J.; NEČAS, A.; CRHA, M.; PROKS, P.; PLÁNKA, L.
Vydáno
1. 11. 2013
Nakladatel
TRM, Leipzig
Místo
Leipzig, Germany
ISSN
1746-0751
Periodikum
Regenerative Medicine
Ročník
8
Číslo
6
Stát
Spojené království Velké Británie a Severního Irska
Strany od
192
Strany do
Strany počet
426
BibTex
@misc{BUT104595, author="Lucy {Vojtová} and Josef {Jančář} and Jana {Juhásová} and Alois {Nečas} and Michal {Crha} and Pavel {Proks} and Ladislav {Plánka}", title="Regeneration of articular cartilage and growth plate by 3D resorbable biopolymer composites seeded with mesenchymal stem cells and chondrocytes", year="2013", journal="Regenerative Medicine", volume="8", number="6", pages="192--192", publisher="TRM, Leipzig", address="Leipzig, Germany", issn="1746-0751", note="abstract" }