Detail publikace

Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods

KOMÍNKOVÁ, M. GURÁŇ, R. MERLOS RODRIGO, M. KOPEL, P. BLAŽKOVÁ, I. CHUDOBOVÁ, D. NEJDL, L. HEGER, Z. RUTTKAY-NEDECKÝ, B. ZÍTKA, O. ADAM, V. KIZEK, R.

Originální název

Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

This study points to changes in the properties of liposomes and its functional qualities in task of release of encapsulated drug doxorubicin according to the content of cholesterol in the phospholipid bilayer. The influence of sodium dodecyl sulphate (SDS) addition to liposomal variants was also evaluated too. Three variants of liposomes differing in various concentrations of cholesterol were assessed. Firstly, we focused on the toxicity of all liposomal variants to Staphyloccocus aureus and it was found that the content of cholesterol increases the IC50 values of encapsulated doxorubicin in liposome with higher concentration of cholesterol than in liposome without cholesterol even four times.

Klíčová slova

Liposome; Cholesterol; Doxorubicin; Sodium Dodecyl Sulphate; Drug Delivery; Drug Encapsulation;

Autoři

KOMÍNKOVÁ, M.; GURÁŇ, R.; MERLOS RODRIGO, M.; KOPEL, P.; BLAŽKOVÁ, I.; CHUDOBOVÁ, D.; NEJDL, L.; HEGER, Z.; RUTTKAY-NEDECKÝ, B.; ZÍTKA, O.; ADAM, V.; KIZEK, R.

Rok RIV

2014

Vydáno

23. 3. 2014

ISSN

1452-3981

Periodikum

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE

Ročník

9

Číslo

6

Stát

Srbská republika

Strany od

2993

Strany do

3007

Strany počet

15

BibTex

@article{BUT106912,
  author="Markéta {Komínková} and Roman {Guráň} and Miguel Ángel {Merlos Rodrigo} and Pavel {Kopel} and Iva {Blažková} and Dagmar {Hegerová} and Lukáš {Nejdl} and Zbyněk {Heger} and Branislav {Ruttkay-Nedecký} and Ondřej {Zítka} and Vojtěch {Adam} and René {Kizek}",
  title="Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods",
  journal="INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE",
  year="2014",
  volume="9",
  number="6",
  pages="2993--3007",
  issn="1452-3981"
}