Detail publikace

Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxophthalazin-2yl] acetic acid hydrazide derivatives

EL-SHAMY, I. ABDEL-LATTIF, A. AL MAHMOUD ALSHEIKH, A. FOUDA, M. ELDEYAB, S. EL-HASHASH, M. JANČÁŘ, J.

Originální název

Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxophthalazin-2yl] acetic acid hydrazide derivatives

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The phthalazine carbohydrazide 2 was prepared and incorporated into the corresponding 1,2,4-triazole and carbamate derivatives. Phthalazine carboxylic acid hydrazide 2 was treated with isatine and cyclohexanone to give the corresponding hydrazone derivatives 16, 19 in good yields. Furthermore, a-amino acid derivative conjugated with 1-oxophthalazine moiety 35 was synthesized by the reaction of the corresponding aizde 28, via the azide-coupling method, with glycine methyl ester. The peptide ester 35 was converted into their orresponding amide 36 by treating with methanolic ammonia. Moreover, 35 was boiled with hydrazine hydrate to afford the corresponding hydrazide 37. Finally, the dipeptide 38 was prepared by coupling of 35 with L-alanine methyl ester. Some of these compounds were screened in vitro for their antimicrobial activity. The energy gap between the highest occupied molecular orbital and lowest unoccupied molecular orbital has been calculated using the theoretical computations to reflect the chemical reactivity and kinetic stability of compounds.

Klíčová slova

Synthesis, Phthalazine, Quantum calculation, Carbohydrazide, Biological, Anti-inflammatory activities

Autoři

EL-SHAMY, I.; ABDEL-LATTIF, A.; AL MAHMOUD ALSHEIKH, A.; FOUDA, M.; ELDEYAB, S.; EL-HASHASH, M.; JANČÁŘ, J.

Rok RIV

2015

Vydáno

15. 2. 2015

ISSN

0143-7208

Periodikum

DYES AND PIGMENTS

Ročník

113

Číslo

357

Stát

Spojené království Velké Británie a Severního Irska

Strany od

357

Strany do

371

Strany počet

15

BibTex

@article{BUT109643,
  author="Ibrahim E. {El-Shamy} and Abdelmohsen Moustafa {Abdellatif} and Amer {Al Mahmoud Alsheikh} and Moustafa {Fouda} and Salam {Eldeyab} and Mather {El-hashash} and Josef {Jančář}",
  title="Synthesis, biological, anti-inflammatory activities and quantum chemical calculation of some [4-(2, 4, 6-trimethylphenyl)-1(2H)-oxophthalazin-2yl] acetic acid hydrazide derivatives",
  journal="DYES AND PIGMENTS",
  year="2015",
  volume="113",
  number="357",
  pages="357--371",
  doi="10.1016/j.dyepig.2014.08.026",
  issn="0143-7208"
}