Detail publikace

Effect of Ampicillin, Streptomycin, Penicillin and Tetracycline on Metal Resistant and Non-Resistant Staphylococcus aureus

CHUDOBOVÁ, D. DOSTÁLOVÁ, S. BLAŽKOVÁ, I. MICHÁLEK, P. RUTTKAY-NEDECKÝ, B. SKLENÁŘ, M. NEJDL, L. KUDR, J. GUMULEC, J. TMEJOVÁ, K. KONEČNÁ, M. VACULOVIČOVÁ, M. HYNEK, D. MASAŘÍK, M. KYNICKÝ, J. KIZEK, R. ADAM, V.

Originální název

Effect of Ampicillin, Streptomycin, Penicillin and Tetracycline on Metal Resistant and Non-Resistant Staphylococcus aureus

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

There is an arising and concerning issue in the field of bacterial resistance, which is confirmed by the number of deaths associated with drug-resistant bacterial infections. The aim of this study was to compare the effects of antibiotics on Staphylococcus aureus non-resistant strain and strains resistant to cadmium or lead ions. Metal resistant strains were created by the gradual addition of 2 mM solution of metal ions (cadmium or lead) to the S. aureus culture. An increasing antimicrobial effect of ampicillin, streptomycin, penicillin and tetracycline (0, 10, 25, 50, 75, 150, 225 and 300 mu M) on the resistant strains was observed using a method of growth curves. A significant growth inhibition (compared to control) of cadmium resistant cells was observed in the presence of all the four different antibiotics. On the other hand, the addition of streptomycin and ampicillin did not inhibit the growth of lead resistant strain. Other antibiotics were still toxic to the bacterial cells. Significant differences in the morphology of cell walls were indicated by changes in the cell shape. Our data show that the presence of metal ions in the urban environment may contribute to the development of bacterial strain resistance to other substances including antibiotics, which would have an impact on public health.

Klíčová slova

S. aureus; antimicrobial resistance; antibiotics; metal resistance; cross resistance; growth curves; inhibition concentrations; spectrophotometry

Klíčová slova v angličtině

S. aureus; antimicrobial resistance; antibiotics; metal resistance; cross resistance; growth curves; inhibition concentrations; spectrophotometry

Autoři

CHUDOBOVÁ, D.; DOSTÁLOVÁ, S.; BLAŽKOVÁ, I.; MICHÁLEK, P.; RUTTKAY-NEDECKÝ, B.; SKLENÁŘ, M.; NEJDL, L.; KUDR, J.; GUMULEC, J.; TMEJOVÁ, K.; KONEČNÁ, M.; VACULOVIČOVÁ, M.; HYNEK, D.; MASAŘÍK, M.; KYNICKÝ, J.; KIZEK, R.; ADAM, V.

Rok RIV

2014

Vydáno

19. 3. 2014

Nakladatel

MDPI AG, POSTFACH

Místo

CH-4005 BASEL, SWITZERLAND

ISSN

1660-4601

Periodikum

International Journal of Environmental Research and Public Health

Ročník

2014

Číslo

3

Stát

Švýcarská konfederace

Strany od

3233

Strany do

3255

Strany počet

23

URL

http://www.mdpi.com/1660-4601/11/3/3233

Plný text v Digitální knihovně

http://hdl.handle.net/11012/63711

BibTex

@article{BUT112144,
  author="Dagmar {Hegerová} and Simona {Dostálová} and Iva {Blažková} and Petr {Michálek} and Branislav {Ruttkay-Nedecký} and Matěj {Sklenář} and Lukáš {Nejdl} and Jiří {Kudr} and Jaromír {Gumulec} and Kateřina {Tmejová} and Marie {Konečná} and Markéta {Vaculovičová} and David {Hynek} and Michal {Masařík} and Jindřich {Kynický} and René {Kizek} and Vojtěch {Adam}",
  title="Effect of Ampicillin, Streptomycin, Penicillin and Tetracycline on Metal Resistant and Non-Resistant Staphylococcus aureus",
  journal="International Journal of Environmental Research and Public Health",
  year="2014",
  volume="2014",
  number="3",
  pages="3233--3255",
  doi="10.3390/ijerph110303233",
  issn="1660-4601",
  url="http://www.mdpi.com/1660-4601/11/3/3233"
}