Detail publikace

Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach

SOCHOR, J. NEJDL, L. RUTTKAY-NEDECKÝ, B. BEZDĚKOVÁ, A. LUKEŠOVÁ, K. ZÍTKA, O. CERNEI, N. MAREŠ, P. POHANKA, M. ADAM, V. BABULA, P. BEKLOVÁ, M. ZEMAN, L. KIZEK, R.

Originální název

Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Taurine (2-aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues. It is involved in many physiological processes. Thus, it is widely discussed especially due to its antioxidant properties. In this study, we focused on the effect of taurine supplementation on the concentration of antioxidants in blood plasma and erythrocytes of Wistar rats. Taurine was applied in feed mixture in the dosage of 0, 1, 250, 500, 750, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg. We monitored both enzymatic and non-enzymatic antioxidants - glutathione peroxidase, glutathione reductase, and superoxide dismutase and reduced/oxidized glutathione and metallothionein. Using three different methods 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Ferric Reducing Antioxidant Power (FRAP) and free radicals, we determined antioxidant capacity. In addition, we monitored levels of uric acid and glucose. Our results revealed significant changes in both enzymatic and non-enzymatic parameters with the increasing taurine supplementation. (C) 2013 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Klíčová slova

Taurine; Thiol antioxidant; Oxidative stress; Glutathione; Metallothionein; Wistar rats

Autoři

SOCHOR, J.; NEJDL, L.; RUTTKAY-NEDECKÝ, B.; BEZDĚKOVÁ, A.; LUKEŠOVÁ, K.; ZÍTKA, O.; CERNEI, N.; MAREŠ, P.; POHANKA, M.; ADAM, V.; BABULA, P.; BEKLOVÁ, M.; ZEMAN, L.; KIZEK, R.

Rok RIV

2014

Vydáno

1. 4. 2014

Nakladatel

UNIV SOUTH BOHEMIA, FAC HEALTH & SOCIAL STUD, JIROVCOVA, CESKA BUDEJOVICE, 370 04, CZECH REPUBLIC

Místo

CESKA BUDEJOVICE, 370 04, CZECH REPUBLIC

ISSN

1214-021X

Periodikum

J APPL BIOMED

Ročník

12

Číslo

2

Stát

Česká republika

Strany od

97

Strany do

110

Strany počet

14

URL

http://www.sciencedirect.com/science/article/pii/S1214021X13000094

BibTex

@article{BUT112150,
  author="Jiří {Sochor} and Lukáš {Nejdl} and Branislav {Ruttkay-Nedecký} and Andrea {Bezděková} and Kateřina {Lukešová} and Ondřej {Zítka} and Natalia Vladimirovna {Cernei} and Petr {Mareš} and Miroslav {Pohanka} and Vojtěch {Adam} and Petr {Babula} and Miroslava {Beklová} and Ladislav {Zeman} and René {Kizek}",
  title="Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach",
  journal="J APPL BIOMED",
  year="2014",
  volume="12",
  number="2",
  pages="97--110",
  doi="10.1016/j.jab.2013.01.002",
  issn="1214-021X",
  url="http://www.sciencedirect.com/science/article/pii/S1214021X13000094"
}