Detail publikace

Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine

EL-SHAMY, I. ABDEL-LATTIF, A. FOUDA, M. AL-DEYAB, S. EL-HASHASH, M.

Originální název

Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

1-Chloro-4-(2,4,6-trimethylphenyl)phthalazine (2) was used as a precursor for preparation of some novel pyrazolylphthalazine derivatives 6-13 and 15-19. Moreover, the acyclonucleosides 20-23 a-e were prepared by the reaction of hydrazinophthalazine derivative 3 with different aldoses. All new phthalazine derivatives were characterized using 1H NMR, 13C NMR, FTIR, mass spectrum and elemental analysis. The newly synthesized compounds showed highly activity against different species of bacteria and fungi, in addition to an excellent antiinflammatory property.

Klíčová slova

C-nucleosides, Phthalazine derivatives, Biological activity

Autoři

EL-SHAMY, I.; ABDEL-LATTIF, A.; FOUDA, M.; AL-DEYAB, S.; EL-HASHASH, M.

Rok RIV

2014

Vydáno

1. 7. 2014

ISSN

0970-7077

Periodikum

ASIAN JOURNAL OF CHEMISTRY

Ročník

26

Číslo

14

Stát

Indická republika

Strany od

4405

Strany do

4415

Strany počet

11

BibTex

@article{BUT112240,
  author="Ibrahim E. {El-Shamy} and Abdelmohsen Moustafa {Abdellatif} and Moustafa M.D. {Fouda} and Salem S. {Al-Deyab} and Maher A. {El-Hashash}",
  title="Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine",
  journal="ASIAN JOURNAL OF CHEMISTRY",
  year="2014",
  volume="26",
  number="14",
  pages="4405--4415",
  issn="0970-7077"
}