Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control

článek v časopise ve Web of Science, Jimp

angličtina

Impaired speech prosody is common in Parkinson's disease (PD). We assessed the impact of PD and levodopa on MRI resting-state functional connectivity (rs-FC) underlying speech prosody control. We studied 19 PD patients in the OFF and ON dopaminergic conditions and 15 age-matched healthy controls using functional MRI and seed partial least squares correlation (PLSC) analysis. In the PD group, we also correlated levodopa-induced rs-FC changes with the results of acoustic analysis. The PLCS analysis revealed a significant impact of PD but not of medication on the rs-FC strength of spatial correlation maps seeded by the anterior cingulate (p = 0.006), the right orofacial primary sensorimotor cortex (OF_SM1; p = 0.025) and the right caudate head (CN; p = 0.047). In the PD group, levodopa-induced changes in the CN and OF_SM1 connectivity strengths were related to changes in speech prosody. We demonstrated an impact of PD but not of levodopa on rs-FC within the brain networks related to speech prosody control. When only the PD patients were taken into account, the association between treatment-induced changes in speech prosody and changes in rs-FC within the associative striato-prefrontal and motor speech networks was found.

Parkinson's disease, functional connectivity, speech prosody, fMRI, resting state, dopaminergic, levodopa, acoustic, motor speech network, caudate nucleus

ELFMARKOVA, N.; GAJDOŠ, M.; MRAČKOVÁ, M.; MEKYSKA, J.; MIKL, M.; REKTOROVÁ, I.

4. 1. 2016

1353-8020

PARKINSONISM & RELATED DISORDERS

22

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Spojené království Velké Británie a Severního Irska

S52

S55

4