Detail publikace

Bipartite Graphs for Metagenomic Data Analysis and Visualization

SEDLÁŘ, K. ŠKUTKOVÁ, H. VÍDEŇSKÁ, P. RYCHLÍK, I. PROVAZNÍK, I.

Originální název

Bipartite Graphs for Metagenomic Data Analysis and Visualization

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

Metagenomics became very popular after expansion of next-generation sequencing techniques that allowed simple implementation of extensive studies. With a target gene sequencing approach, an identification of organisms in a metagenome is quite effortless since only a small reference database of the particular gene is needed. Moreover, by counting the copies of individual genes, also quantitative analysis can be applied. Unfortunately, current bioinformatics tools aim mainly on the analysis of a single metagenome. A cluster analysis, a heatmap of correlation coefficients, biclustering or other statistics techniques can only show relations inside the metagenome or the relation between the metagenome composition and other parameters. On the other hand, there is a lack of tools to provide a comparative analysis of two or more metagenomes. Suitable properties for this kind of analysis can be found in a bipartite graph. Here, we present a novel workflow for finding the suitable representation of metagenomic data to provide a comparative analysis of metagenomes. The resulting graph can take into account information about the actual composition of the metagenome as well as the environment it relates to. Thus, it can provide different view of the data to the naked eye that can complement other techniques such as principal coordinate analysis.

Klíčová slova

metagenomics; 16S rRNA; bipartite graph; visualization

Autoři

SEDLÁŘ, K.; ŠKUTKOVÁ, H.; VÍDEŇSKÁ, P.; RYCHLÍK, I.; PROVAZNÍK, I.

Rok RIV

2015

Vydáno

9. 11. 2015

Nakladatel

IEEE

Místo

Washington D.C.

ISBN

978-1-4673-6798-1

Kniha

Proceedings 2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2015)

Edice

1

Číslo edice

1

Strany od

1123

Strany do

1128

Strany počet

6

URL

https://ieeexplore.ieee.org/document/7359839

BibTex

@inproceedings{BUT118376,
  author="Karel {Sedlář} and Helena {Vítková} and Petra {Vídeňská} and Ivan {Rychlík} and Valentine {Provazník}",
  title="Bipartite Graphs for Metagenomic Data Analysis and Visualization",
  booktitle="Proceedings 2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2015)",
  year="2015",
  series="1",
  number="1",
  pages="1123--1128",
  publisher="IEEE",
  address="Washington D.C.",
  doi="10.1109/BIBM.2015.7359839",
  isbn="978-1-4673-6798-1",
  url="https://ieeexplore.ieee.org/document/7359839"
}