Detail publikace

Optimization of derivatization of acidic drugs for analysis by GC-MS and its application for determination of drug residues in wastewater

SÝKORA, R. VÁVROVÁ, M. MRAVCOVÁ, L. LACINA, P.

Originální název

Optimization of derivatization of acidic drugs for analysis by GC-MS and its application for determination of drug residues in wastewater

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

This article is focused on optimization of derivatization of acidic drugs from the group of non-steroidal anti-inflammatory drugs (NSAID): salicylic acid, ibuprofen, naproxen, ketoprofen and diclofenac. Derivatization is a necessary step for analysis of pharmaceuticals by GC. MSTFA (N-methylN-(trimethylsilyl)trifluoroacetamide) and BSTFA (N,Obis(trimethylsilyl)trifluoroacetamide) were used as a derivatization reagents and tested under different conditions: volume, temperature and time of derivatization. Results of optimization were compared and optimized conditions were successfully applied for analysis of real samples of wastewater. Wastewater samples were collected from influent and effluent of wastewater treatment plant (WWTP). The whole analytical procedure involved solid phase extraction (SPE), optimized derivatization and analysis by GC-TOF MS. Limits of detection (LOD) ranged between 8.9 - 71.6 ng.L-1 and limits of quantification (LOQ) ranged between 29.5 – 238.7 ng.L-1 depending on the specific compound. Concentration of selected drugs in real samples of wastewater varied from 0.1 to 30 g.L-1 in influent and from 0.05 to 2 g.L-1 in effluent, depending on the compound.

Klíčová slova

Non-steroidal anti-inflammatory drugs, derivatization, silylation, derivatization reagents, gas chromatography, wastewater

Autoři

SÝKORA, R.; VÁVROVÁ, M.; MRAVCOVÁ, L.; LACINA, P.

Rok RIV

2015

Vydáno

1. 12. 2015

ISSN

1018-4619

Periodikum

Fresenius Environmental Bulletin

Ročník

24

Číslo

11a

Stát

Spolková republika Německo

Strany od

3813

Strany do

3821

Strany počet

9

BibTex

@article{BUT118998,
  author="Richard {Sýkora} and Milada {Vávrová} and Ludmila {Mravcová} and Petr {Lacina}",
  title="Optimization of derivatization of acidic drugs for analysis by GC-MS and its application for determination of drug residues in wastewater",
  journal="Fresenius Environmental Bulletin",
  year="2015",
  volume="24",
  number="11a",
  pages="3813--3821",
  issn="1018-4619"
}