Detail publikace

Study on Mutual Interactions and Electronic Structures of Hyaluronan with Lysine, 6-Aminocaproic Acid and Arginine

Chytil M , Trojan M , Kovalenko A

Originální název

Study on Mutual Interactions and Electronic Structures of Hyaluronan with Lysine, 6-Aminocaproic Acid and Arginine

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Interactions between polyelectrolytes and oppositely charged surfactants have been in a great interest for several decades, yet the conventional surfactants may cause a problem in medical applications. Interactivity between polysaccharide hyaluronan (HA) and amino acids Lysine, 6-Aminocaproic acid (6-AcA), and Arginine as an alternative system is reported. The interactions were investigated by means of rheology and electric conductance and the electronic structures were explored by the density functional theory (DFT). Lysine exhibits the strongest interaction of all, which was manifested, e.g. by nearly 6-time drop of the initial viscosity comparing with only 1.3-time lower value in the case of 6-AcA. Arginine interaction with HA was surprisingly weaker in terms of viscosity than that of Lysine due to a lower and delocalized charge density on its guanidine group. According to the DFT calculations, the binding of Lysine to HA was found to be more flexible, while Arginine creates more rigid structure with HA.

Klíčová slova

hyaluronan, amino acids, interactions, rheology, density functional theory (DFT)

Autoři

Chytil M , Trojan M , Kovalenko A

Vydáno

20. 5. 2016

Nakladatel

Elsevier

ISSN

0144-8617

Periodikum

Carbohydrate Polymers

Ročník

142

Stát

Spojené království Velké Británie a Severního Irska

Strany od

8

Strany do

15

Strany počet

8

URL

http://www.sciencedirect.com/science/article/pii/S0144861716000503

BibTex

@article{BUT126482,
  author="Alexander {Kovalenko}",
  title="Study on Mutual Interactions and Electronic Structures of Hyaluronan with Lysine, 6-Aminocaproic Acid and Arginine",
  journal="Carbohydrate Polymers",
  year="2016",
  volume="142",
  number="0",
  pages="8--15",
  doi="10.1016/j.carbpol.2016.01.035",
  issn="0144-8617",
  url="http://www.sciencedirect.com/science/article/pii/S0144861716000503"
}