Detail publikace

Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC

POLANSKÁ, H. HEGER, Z. GUMULEC, J. RAUDENSKÁ, M. SVOBODOVÁ, M. BALVAN, J. FOJTŮ, M. BINKOVÁ, H. HORÁKOVÁ, Z. KOSTŘICA, R. ADAM, V. KIZEK, R. MASAŘÍK, M.

Originální název

Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Approximately 90 % of head and neck cancers are squamous cell carcinomas (HNSCC), and the overall 5-year survival rate is not higher than 50 %. There is much evidence that human papillomavirus (HPV) infection may influence the expression of commonly studied HNSCC markers. Our study was focused on the possible HPV-specificity of molecular markers that could be key players in important steps of cancerogenesis (MKI67, EGF, EGFR, BCL-2, BAX, FOS, JUN, TP53, MT1A, MT2A, VEGFA, FLT1, MMP2, MMP9, and POU5F). qRT-PCR analysis of these selected genes was performed on 74 biopsy samples of tumors from patients with histologically verified HNSCC (22 HPV–, 52 HPV+). Kaplan- Meier analysis was done to determine the relevance of these selected markers for HNSCC prognosis. In conclusion, our study confirms the impact of HPV infection on commonly studied HNSCC markers MT2A, MMP9, FLT1, VEGFA, and POU5F that were more highly expressed in HPV-negative HNSCC patients and also shows the relevance of studied markers in HPV-positive and HPV-negative HNSCC patients.

Klíčová slova

Head and neck cancer, Human papillomavirus . Tumormarkers . Kaplan-Meier analysis

Autoři

POLANSKÁ, H.; HEGER, Z.; GUMULEC, J.; RAUDENSKÁ, M.; SVOBODOVÁ, M.; BALVAN, J.; FOJTŮ, M.; BINKOVÁ, H.; HORÁKOVÁ, Z.; KOSTŘICA, R.; ADAM, V.; KIZEK, R.; MASAŘÍK, M.

Vydáno

1. 6. 2016

ISSN

1010-4283

Periodikum

TUMOR BIOLOGY

Ročník

37

Číslo

6

Stát

Švýcarská konfederace

Strany od

7193

Strany do

7201

Strany počet

9

BibTex

@article{BUT128494,
  author="Hana {Polanská} and Zbyněk {Heger} and Jaromír {Gumulec} and Martina {Raudenská} and Markéta {Svobodová} and Jan {Balvan} and Michaela {Fojtů} and Hana {Binková} and Zuzana {Horáková} and Rom {Kostřica} and Vojtěch {Adam} and René {Kizek} and Michal {Masařík}",
  title="Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC",
  journal="TUMOR BIOLOGY",
  year="2016",
  volume="37",
  number="6",
  pages="7193--7201",
  doi="10.1007/s13277-015-4569-6",
  issn="1010-4283"
}