Detail publikace

Finite element simulation of mechanical tests with bendo-tensegrity models of smooth muscle cell.

BANSOD, Y. BURŠA, J.

Originální název

Finite element simulation of mechanical tests with bendo-tensegrity models of smooth muscle cell.

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

It is now evident that microtubules do not have compression-only behavior but appear highly curved in living cells under no external load. This indicates that the compressive forces in them are accompanied by significant bending even if loaded solely by the prestrained actin bundles; this is referred to as the “bendo-tensegrity” concept. Implementing this concept, finite element models of smooth muscle cell (SMC) are proposed considering the dominating role of flexion in behavior of microtubules. A Finite element simulation of atomic force microscopy (AFM) experiment with adherent cell model and tensile test with suspended cell model is performed. The numerically predicted force-displacement curves of both simulations are analogous to the non-linear experimental responses obtained with AFM and tensile test for SMC; this validates the proposed bendo-tensegrity cell models. Results show that the actin cortex plays a vital role in maintaining the cell rigidity under local deformation, whereas the microfilaments, microtubules and intermediate filaments contribute significantly to the cell response under global deformation.

Klíčová slova

Cytoskeleton, Bendo-tensegrity, FInite element modelling, Cell mechanics

Autoři

BANSOD, Y.; BURŠA, J.

Vydáno

18. 5. 2016

Nakladatel

XXIV Cytoskeletal Club, Veterinary Research Institute, Masaryk University.

Místo

Vranovska Ves, Czech Republic.

BibTex

@misc{BUT129891,
  author="Yogesh Deepak {Bansod} and Jiří {Burša}",
  title="Finite element simulation of mechanical tests with bendo-tensegrity models of smooth muscle cell.",
  year="2016",
  publisher="XXIV Cytoskeletal Club, Veterinary Research Institute, Masaryk University.",
  address="Vranovska Ves, Czech Republic.",
  note="abstract"
}