Bone Remodeling Algorithm Incorporating Various Quantities as Mechanical Stimulus and Assuming Initial Microcrack in Bone

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angličtina

It is widely accepted that bones have the ability to adapt to new biomechanical environment by changing their material properties, geometry and inner architecture. Bones have also an exceptional ability to self-repair, to remove microcracks and to prevent the bone damage caused by the fatigue failure. These abilities are enabled through coupled processes of bone resorption and bone formation, the processes collectively referred to as bone remodeling. Numerous studies have shown that bone remodeling is governed by combination of mechanical stimulus (strains) and its frequency, both sensed by sensor cells (osteocytes). Through mechanotransduction, the stimulus is transmitted to actor cells (osteoclasts, osteoblasts) that actually do the bone resorption or formation. Several theories have been proposed to predict bone remodeling and several finite-element-based algorithms have been introduced. The vast majority of them uses strain energy density as the mechanical stimulus. The purpose of this paper is to investigate and discuss the applicability of also other strain-based representations of the mechanical stimulus in simulations of remodeling of bone with an initial microcrack. The need for developing more reliable models is essential for both clinicians and engineers who are interested, for instance, in prediction of bone performance when various implants are involved.

bone remodeling; strain; microdamage; mechano-regulation; finite element method

BORÁK, L.; MARCIÁN, P.

1. 9. 2017

1662-9795

Key Engineering Materials (web)

754

Švýcarská konfederace

189

193

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