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NOVOTNÁ, P. HEJČ, J. RONZHINA, M. JANOUŠEK, O. STRAČINA, T. OLEJNÍČKOVÁ, V. NOVÁKOVÁ, M. KOLÁŘOVÁ, J.
Originální název
Analysis of Hemodynamic Related Changes in High Frequency Content of QRS Complex in Working Isolated Rabbit Heart
Typ
článek ve sborníku ve WoS nebo Scopus
Jazyk
angličtina
Originální abstrakt
Aim: High frequency content of QRS complex (HF-QRS) is thought to be related to local conduction velocity (CV). There also exists the evidence suggesting the coupling between CV and mechanical stretch via so-called mechano-electric feedback. The aim of this study was to investigate possible relationship between left ventricular (LV) load and the most common HF-QRS parameters. Methods: Six isolated rabbit hearts in working mode underwent an experimental protocol consisting of upward and downward steps in preload (8-11 cmH2O). Eight unipolar pseudo-ECGs, left atrial pressure, and flow rate were recorded at fs=10 kHz and 16-bit resolution. QRS complexes from hemodynamically stable experiment phase were clustered, aligned, and decomposed into 3 HF-QRS bands followed by the assessment of power envelope RMS, the tallest peak value and its position. Results: No statistically significant changes associated with LV load alteration were observed in HF-QRS parameter. Conclusion: No evidence of load dependent changes in conduction velocity was found in the study. However, HF signal may represent a complex spatial depolarization behavior. Low sensitivity of used metrics should also be taken into consideration.
Klíčová slova
ventricular repolarization, ventricular load, preload, high-frequency analysis, mechano-electric coupling, dynamic response, isolated heart, working heart
Autoři
NOVOTNÁ, P.; HEJČ, J.; RONZHINA, M.; JANOUŠEK, O.; STRAČINA, T.; OLEJNÍČKOVÁ, V.; NOVÁKOVÁ, M.; KOLÁŘOVÁ, J.
Vydáno
30. 9. 2017
Nakladatel
Computing in Cardiology 2017
Místo
Rennes, France
ISBN
978-1-5090-0684-7
Kniha
Edice
44
Číslo edice
1
ISSN
0276-6574
Periodikum
Computers in Cardiology
Stát
Spojené státy americké
Strany od
Strany do
4
Strany počet
BibTex
@inproceedings{BUT140440, author="Petra {Novotná} and Jakub {Hejč} and Marina {Filipenská} and Oto {Janoušek} and Tibor {Stračina} and Veronika {Olejníčková} and Marie {Nováková} and Jana {Kolářová}", title="Analysis of Hemodynamic Related Changes in High Frequency Content of QRS Complex in Working Isolated Rabbit Heart", booktitle="Computing in Cardiology 2017", year="2017", series="44", journal="Computers in Cardiology", number="1", pages="1--4", publisher="Computing in Cardiology 2017", address="Rennes, France", doi="10.22489/CinC.2017.293-442", isbn="978-1-5090-0684-7", issn="0276-6574" }