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JANOUŠEK, O. STRAČINA, T. RONZHINA, M. HEJČ, J. STARK, T. RUDA, J. MICALE, V. KOLÁŘOVÁ, J. NOVÁKOVÁ, M. PROVAZNÍK, I.
Originální název
The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats
Typ
článek ve sborníku ve WoS nebo Scopus
Jazyk
angličtina
Originální abstrakt
Deeper understanding of heart rate variability (HRV) changes induced by haloperidol administration can contribute to overcoming of adverse cardiovascular effects of antipsychotics. The effect of haloperidol administration on HRV was therefore studied in nine schizophrenia-like rat isolated hearts and six control rat hearts. Isolated hearts were stabilized (20 min) on Langendorff perfusion system, then exposed to haloperidol (40 min) and finally washed out (40 min). The effect of haloperidol administration was studied in tachograms obtained from touchless-recorded electrograms (5 kHz, 12-bit). HRV parameters evolution in time, frequency, geometric, and non-linear domain were computed from 10 minutes long tachogram segments during stabilization, haloperidol exposition and washout periods. The haloperidol administration significantly affected HRV parameters in control rat hearts, but it had limited effect on schizophrenia-like ones. The effect of haloperidol administration was irreversible, since the washout did not restore HRV parameters to their initial values.
Klíčová slova
Heart Rate Variability; Haloperidol
Autoři
JANOUŠEK, O.; STRAČINA, T.; RONZHINA, M.; HEJČ, J.; STARK, T.; RUDA, J.; MICALE, V.; KOLÁŘOVÁ, J.; NOVÁKOVÁ, M.; PROVAZNÍK, I.
Vydáno
30. 9. 2017
Nakladatel
Computing in Cardiology 2017
Místo
Rennes, France
ISBN
978-1-5090-0684-7
Kniha
Computing in Cardiology, 2017
Edice
44
Číslo edice
1
ISSN
0276-6574
Periodikum
Computers in Cardiology
Stát
Spojené státy americké
Strany od
Strany do
4
Strany počet
BibTex
@inproceedings{BUT141020, author="Oto {Janoušek} and Tibor {Stračina} and Marina {Filipenská} and Jakub {Hejč} and Tibor {Stark} and Jana {Ruda} and Vincenzo {Micale} and Jana {Kolářová} and Marie {Nováková} and Valentine {Provazník}", title="The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats", booktitle="Computing in Cardiology, 2017", year="2017", series="44", journal="Computers in Cardiology", number="1", pages="1--4", publisher="Computing in Cardiology 2017", address="Rennes, France", doi="10.22489/CinC.2017.150-161", isbn="978-1-5090-0684-7", issn="0276-6574" }