Detail publikace

Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation

HEGER, Z. ZÍTKA, O. KŘÍŽKOVÁ, S. BEKLOVÁ, M. KIZEK, R. ADAM, V.

Originální název

Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Group of estrogen pollutants, where the highest estrogen activity is reported at estradiol, is characterized by the fact that even at very low concentrations have potential to cause xenoestrogenic effects. During exposure of excessive amounts of estradiols may be produced undesirable effects resulting in the feminization of males of water organisms. The presence of estradiols in drinking water implies also a risk for the human population in the form of cancers of endocrine systems, abnormalities in reproduction or dysfunctions of neuronal and immune system. Currently, the research is focused mainly to uncover the relationship between the estrogen receptors binding affinity with an estrogen response element and estradiol. In this review we summarized facts about molecular biological principles of beta estradiol-estrogen receptor complex binding with estrogen response element and its successive effect on cancer genes expression.

Klíčová slova

estradiol; estrogen response element; estrogen receptor; ligand binding domain; DNA binding domain

Autoři

HEGER, Z.; ZÍTKA, O.; KŘÍŽKOVÁ, S.; BEKLOVÁ, M.; KIZEK, R.; ADAM, V.

Vydáno

1. 12. 2013

ISSN

0172-780X

Periodikum

NEUROENDOCRINOLOGY LETTERS

Ročník

34

Číslo

2

Stát

Švédské království

Strany od

123

Strany do

129

Strany počet

7

BibTex

@article{BUT142340,
  author="Zbyněk {Heger} and Ondřej {Zítka} and Soňa {Křížková} and Miroslava {Beklová} and René {Kizek} and Vojtěch {Adam}",
  title="Molecular biology of beta-estradiol-estrogen receptor complex binding to estrogen response element and the effect on cell proliferation",
  journal="NEUROENDOCRINOLOGY LETTERS",
  year="2013",
  volume="34",
  number="2",
  pages="123--129",
  issn="0172-780X"
}