Detail publikace

LIPOSOMES AS DRUG CARRIERS AND THEIR CHARACTERIZATION USING DIFFERENT ANALYTICAL METHODS

GURÁŇ, R. KOMÍNKOVÁ, M. KOPEL, P. CHUDOBOVA, D. ZÍTKA, O. ADAM, V. KIZEK, R.

Originální název

LIPOSOMES AS DRUG CARRIERS AND THEIR CHARACTERIZATION USING DIFFERENT ANALYTICAL METHODS

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

The physicochemical properties of liposomes are significantly affected by the composition of phospholipid bilayer; differences in composition allow the use of liposomes for analytical purposes and for therapeutic purposes. One of the most used components of phospholipid bilayer is cholesterol. Its concentration plays a significant role in the behaviour of liposomes. This study points to changes in the properties of liposomes and its influence on encapsulated doxorubicin according to the content of cholesterol in the phospholipid bilayer. The influence of SDS addition to liposomal variants was also evaluated. Three variants of liposomes differing in various concentrations of cholesterol were assessed. Firstly, the toxicity of all types of liposomal doxorubicin was evaluated and it was found that the content of cholesterol increases the IC50 values of encapsulated doxorubicin in liposome. The highest concentration of cholesterol in liposome increased the IC50 value even four times compared to liposomes without cholesterol. Secondly, the new approach to compare the influence of different variants of liposomes on detection of carried doxorubicin was used using the electrochemical detection with construction of differential hydrodynamic voltammograms.

Klíčová slova

liposome; cholesterol; doxorubicin; sodium dodecyl sulphate

Autoři

GURÁŇ, R.; KOMÍNKOVÁ, M.; KOPEL, P.; CHUDOBOVA, D.; ZÍTKA, O.; ADAM, V.; KIZEK, R.

Vydáno

21. 11. 2013

ISBN

978-80-7375-908-7

Kniha

MendelNet 2013

Strany od

913

Strany do

918

Strany počet

6

BibTex

@inproceedings{BUT142443,
  author="Roman {Guráň} and Markéta {Komínková} and Pavel {Kopel} and Dagmar {chudobova} and Ondřej {Zítka} and Vojtěch {Adam} and René {Kizek}",
  title="LIPOSOMES AS DRUG CARRIERS AND THEIR CHARACTERIZATION USING DIFFERENT ANALYTICAL METHODS",
  booktitle="MendelNet 2013",
  year="2013",
  pages="913--918",
  isbn="978-80-7375-908-7"
}