Detail publikace

Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis

RESSNEROVÁ, A. RAUDENSKÁ, M. HOLUBOVÁ, M. SVOBODOVÁ, M. POLANSKÁ, H. BABULA, P. MASAŘÍK, M. GUMULEC, J.

Originální název

Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Metals are known for playing essential roles in human physiology. Copper and zinc are trace elements closely dependent on one another and are involved in cell proliferation, growth, gene expression, apoptosis and other processes. Their homeostasis is crucial and tightly controlled by a resourceful system of transporters and transport proteins which deliver copper and zinc ions to their target sites. Abnormal zinc and copper homeostasis can be seen in a number of malignancies and also in head and neck cancer. Imbalance in this homeostasis is observed as an elevation or decrease of copper and zinc ions in serum or tissue levels in patients with cancer. In head and neck cancer these altered levels stand out from those of other malignancies which makes them an object of interest and therefore zinc and copper ions might be a good target for further research of head and neck cancer development and progression. This review aims to summarize the physiological roles of copper and zinc, its binding and transport mechanisms, and based on those, its role in head and neck cancer. To provide stronger evidence, dysregulation of levels is analysed by a meta-analytical approach.

Klíčová slova

Zinc; copper; ceruloplasmin; metallothionein; cancer; head and neck tumour; metallomics; meta-analysis

Autoři

RESSNEROVÁ, A.; RAUDENSKÁ, M.; HOLUBOVÁ, M.; SVOBODOVÁ, M.; POLANSKÁ, H.; BABULA, P.; MASAŘÍK, M.; GUMULEC, J.

Vydáno

1. 1. 2016

ISSN

0929-8673

Periodikum

CURRENT MEDICINAL CHEMISTRY

Ročník

23

Číslo

13

Stát

Stát Spojené arabské emiráty

Strany od

1304

Strany do

1330

Strany počet

27

BibTex

@article{BUT143016,
  author="Alžběta {Ressnerová} and Martina {Raudenská} and Monika {Holubová} and Markéta {Svobodová} and Hana {Polanská} and Petr {Babula} and Michal {Masařík} and Jaromír {Gumulec}",
  title="Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis",
  journal="CURRENT MEDICINAL CHEMISTRY",
  year="2016",
  volume="23",
  number="13",
  pages="1304--1330",
  doi="10.2174/0929867323666160405111543",
  issn="0929-8673"
}