Syntax-Guided Optimal Synthesis for Chemical Reaction Networks

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We study the problem of optimal syntax-guided synthesis of stochastic Chemical Reaction Networks (CRNs) that plays a fundamental role in design automation of molecular devices and in the construction of predictive biochemical models. We propose a sketching language for CRNs that concisely captures syntactic constraints on the network topology and allows its under-specification. Given a sketch, a correctness specification, and a cost function defined over the CRN syntax, our goal is to find a CRN that simultaneously meets the constraints, satisfies the specification and minimizes the cost function. To ensure computational feasibility of the synthesis process, we employ the Linear Noise Approximation allowing us to encode the synthesis problem as a satisfiability modulo theories problem over a set of parametric Ordinary Differential Equations (ODEs). We design and implement a novel algorithm for the optimal synthesis of CRNs that employs almost complete refutation procedure for SMT over reals and ODEs, and exploits a meta-sketching abstraction controlling the search strategy.  Through relevant case studies we demonstrate that our approach significantly improves the capability of existing methods for synthesis of biochemical systems and paves the way towards their automated and provably-correct design.

chemical reaction network design automation optimal synthesis Linear Noise Approximation SMT solvers temporal logic  

ČEŠKA, M.; CARDELLI, L.; FRANZLE, M.; KWIATKOWSKA, M.; LAURENTI, L.; PAOLETTI, N.; WHITBY, M.

2. 5. 2017

Springer Verlag

Heidelberg

978-3-319-63390-9

Proceedings of the 29th International Conference on Computer Aided Verification

Lecture Notes in Computer Science

375

395

20