Detail publikace

Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors

DUŠKOVÁ, K. VESELÝ, Š. DO CARMO SILVA, J. CERNEI, N. ZÍTKA, O. HEGER, Z. ADAM, V. HAVLOVÁ, K. BABJUK, M.

Originální název

Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Background: Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of amino acids and the presence of urological tumors. Materials and Methods: Using ion-exchange chromatography, we tested urine samples of patients with prostate cancer (n = 30), urinary bladder cancer (n = 28), renal cell carcinoma (n = 16) and healthy volunteers (control group; n = 21). Results: In each category, we found a group of amino acids which differed in concentration compared to the control group. These differences were most significant in sarcosine in patients with prostate cancer; leucine, phenylalanine and arginine in those with bladder cancer; and sarcosine, glutamic acid, glycine, tyrosine and arginine in the those with renal cell carcinoma. Conclusion: Results of our research imply a possible connection between the occurrence of specific types of amino acids in the urine and the presence of urological tumors.

Klíčová slova

Amino acids; prostate cancer; renal cell carcinoma; urinary bladder cancer

Autoři

DUŠKOVÁ, K.; VESELÝ, Š.; DO CARMO SILVA, J.; CERNEI, N.; ZÍTKA, O.; HEGER, Z.; ADAM, V.; HAVLOVÁ, K.; BABJUK, M.

Vydáno

1. 4. 2018

Nakladatel

The International Institute of Anticancer Research

ISSN

0258-851X

Periodikum

IN VIVO

Ročník

32

Číslo

2

Stát

Řecká republika

Strany od

425

Strany do

429

Strany počet

5

URL

http://iv.iiarjournals.org/content/32/2/425.abstract

Plný text v Digitální knihovně

http://hdl.handle.net/11012/80179

BibTex

@article{BUT147613,
  author="Kateřina {Dušková} and Štěpán {Veselý} and Joana Isabel {Do Carmo Silva} and Natalia Vladimirovna {Cernei} and Ondřej {Zítka} and Zbyněk {Heger} and Vojtěch {Adam} and Klára {Havlová} and Marek {Babjuk}",
  title="Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors",
  journal="IN VIVO",
  year="2018",
  volume="32",
  number="2",
  pages="425--429",
  doi="10.21873/invivo.11257",
  issn="0258-851X",
  url="http://iv.iiarjournals.org/content/32/2/425.abstract"
}