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Detail publikace
KAUCKA, M. PETERSEN, J. TESAŘOVÁ, M. SZAROWSKA, B. KASTRITI, ME. XIE, M. KICHEVA, A. ANNUSVER, K. PAN, L. SPITZ, F. KAISER, J. HOVORAKOVA, M. ZIKMUND, T. SUNADOME, K. MATISE, MP. WANG, H. MARKLUND, U. ABDO, H. ERNFORS, P. MAIRE, P. WURMSER, M. CHAGIN, AS. FRIED, K. ADAMEYKO, I.
Originální název
Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule turned out to be important for shaping membranous facial bones during development. This suggests that conserved neurosensory structures could benefit from protection and have evolved signals inducing cranial cartilages encasing them. Experiments with mutant mice revealed that the genomic regulatory regions controlling production of SHH in the nervous system contribute to facial cartilage morphogenesis, which might be a mechanism responsible for the adaptive evolution of animal faces and snouts.
Klíčová slova
SONIC HEDGEHOG; CRANIOFACIAL MORPHOGENESIS; SOMITIC CHONDROGENESIS; TRACHEAL CARTILAGE; SHH EXPRESSION; BUD FORMATION; NEURAL-TUBE; ENHANCERS; CELLS; ORIGINS
Autoři
KAUCKA, M.; PETERSEN, J.; TESAŘOVÁ, M.; SZAROWSKA, B.; KASTRITI, ME.; XIE, M.; KICHEVA, A.; ANNUSVER, K.; PAN, L.; SPITZ, F.; KAISER, J.; HOVORAKOVA, M.; ZIKMUND, T.; SUNADOME, K.; MATISE, MP.; WANG, H.; MARKLUND, U.; ABDO, H.; ERNFORS, P.; MAIRE, P.; WURMSER, M.; CHAGIN, AS.; FRIED, K.; ADAMEYKO, I.
Vydáno
13. 6. 2018
ISSN
2050-084X
Periodikum
eLife
Ročník
7
Číslo
1
Stát
Spojené království Velké Británie a Severního Irska
Strany od
e34465
Strany do
Strany počet
27
URL
https://elifesciences.org/articles/34465