Detail publikace

Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease

MEKYSKA, J. GALÁŽ, Z. KISKA, T. ZVONČÁK, V. MUCHA, J. SMÉKAL, Z. ELIÁŠOVÁ, I. KOŠŤÁLOVÁ, M. MRAČKOVÁ, M. FIEDOROVÁ, D. FAUNDEZ-ZANUY, M. SOLÉ-CASALS, J. GÓMEZ-VILDA, P. REKTOROVÁ, I.

Originální název

Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Hypokinetic dysarthria (HD) and freezing of gait (FOG) are both axial symptoms that occur in patients with Parkinson’s disease (PD). It is assumed they have some common pathophysiological mechanisms and therefore that speech disorders in PD can predict FOG deficits within the horizon of some years. The aim of this study is to employ a complex quantitative analysis of the phonation, articulation and prosody in PD patients in order to identify the relationship between HD and FOG, and establish a mathematical model that would predict FOG deficits using acoustic analysis at baseline. We enrolled 75 PD patients who were assessed by 6 clinical scales including the Freezing of Gait Questionnaire (FOG–Q). We subsequently extracted 19 acoustic measures quantifying speech disorders in the fields of phonation, articulation and prosody. To identify the relationship between HD and FOG, we performed a partial correlation analysis. Finally, based on the selected acoustic measures, we trained regression models to predict the change in FOG during a 2-year follow-up. We identified significant correlations between FOG–Q scores and the acoustic measures based on formant frequencies (quantifying the movement of the tongue and jaw) and speech rate. Using the regression models, we were able to predict a change in particular FOG–Q scores with an error of between 7.4 and 17.0 %. This study is suggesting that FOG in patients with PD is mainly linked to improper articulation, a disturbed speech rate and to intelligibility. We have also proved that the acoustic analysis of HD at the baseline can be used as a predictor of the FOG deficit during 2 years of follow-up. This knowledge enables researchers to introduce new cognitive systems that predict gait difficulties in PD patients.

Klíčová slova

Parkinson's disease; hypokinetic dysarthria; freezing of gait; acoustic analysis; quantitative analysis

Autoři

MEKYSKA, J.; GALÁŽ, Z.; KISKA, T.; ZVONČÁK, V.; MUCHA, J.; SMÉKAL, Z.; ELIÁŠOVÁ, I.; KOŠŤÁLOVÁ, M.; MRAČKOVÁ, M.; FIEDOROVÁ, D.; FAUNDEZ-ZANUY, M.; SOLÉ-CASALS, J.; GÓMEZ-VILDA, P.; REKTOROVÁ, I.

Vydáno

1. 12. 2018

ISSN

1866-9956

Periodikum

Cognitive Computation

Ročník

10

Číslo

6

Stát

Spojené státy americké

Strany od

1006

Strany do

1018

Strany počet

13

URL

https://doi.org/10.1007/s12559-018-9575-8

BibTex

@article{BUT149441,
  author="MEKYSKA, J. and GALÁŽ, Z. and KISKA, T. and ZVONČÁK, V. and MUCHA, J. and SMÉKAL, Z. and ELIÁŠOVÁ, I. and KOŠŤÁLOVÁ, M. and MRAČKOVÁ, M. and FIEDOROVÁ, D. and FAUNDEZ-ZANUY, M. and SOLÉ-CASALS, J. and GÓMEZ-VILDA, P. and REKTOROVÁ, I.",
  title="Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease",
  journal="Cognitive Computation",
  year="2018",
  volume="10",
  number="6",
  pages="1006--1018",
  doi="10.1007/s12559-018-9575-8",
  issn="1866-9956",
  url="https://doi.org/10.1007/s12559-018-9575-8"
}