Detail publikace

Non-invasive stimulation of the auditory feedback area for improved articulation in Parkinson's disease

BRABENEC, L. KLOBUŠIAKOVÁ, P. BARTOŇ, M. MEKYSKA, J. GALÁŽ, Z. ZVONČÁK, V. KISKA, T. MUCHA, J. SMÉKAL, Z. KOŠŤÁLOVÁ, M. REKTOROVÁ, I.

Originální název

Non-invasive stimulation of the auditory feedback area for improved articulation in Parkinson's disease

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Introduction Hypokinetic dysarthria (HD) is a common symptom of Parkinson's disease (PD) which does not respond well to PD treatments. We investigated acute effects of repetitive transcranial magnetic stimulation (rTMS) of the motor and auditory feedback area on HD in PD using acoustic analysis of speech. Methods We used 10 Hz and 1 Hz stimulation protocols and applied rTMS over the left orofacial primary motor area, the right superior temporal gyrus (STG), and over the vertex (a control stimulation site) in 16 PD patients with HD. A cross-over design was used. Stimulation sites and protocols were randomised across subjects and sessions. Acoustic analysis of a sentence reading task performed inside the MR scanner was used to evaluate rTMS-induced effects on motor speech. Acute fMRI changes due to rTMS were also analysed. Results The 1 Hz STG stimulation produced significant increases of the relative standard deviation of the 2nd formant (p = 0.019), i.e. an acoustic parameter describing the tongue and jaw movements. The effects were superior to the control site stimulation and were accompanied by increased resting state functional connectivity between the stimulated region and the right parahippocampal gyrus. The rTMS-induced acoustic changes were correlated with the reading task-related BOLD signal increases of the stimulated area (R = 0.654, p = 0.029). Conclusion Our results demonstrate for the first time that low-frequency stimulation of the temporal auditory feedback area may improve articulation in PD and enhance functional connectivity between the STG and the cortical region involved in an overt speech control.

Klíčová slova

Parkinson's disease; hypokinetic dysarthriar; TMS; acoustic analysis; auditory feedback area

Autoři

BRABENEC, L.; KLOBUŠIAKOVÁ, P.; BARTOŇ, M.; MEKYSKA, J.; GALÁŽ, Z.; ZVONČÁK, V.; KISKA, T.; MUCHA, J.; SMÉKAL, Z.; KOŠŤÁLOVÁ, M.; REKTOROVÁ, I.

Vydáno

1. 4. 2019

ISSN

1353-8020

Periodikum

PARKINSONISM & RELATED DISORDERS

Ročník

61

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

187

Strany do

192

Strany počet

6

URL

https://www.sciencedirect.com/science/article/pii/S1353802018304395

BibTex

@article{BUT150820,
  author="BRABENEC, L. and KLOBUŠIAKOVÁ, P. and BARTOŇ, M. and MEKYSKA, J. and GALÁŽ, Z. and ZVONČÁK, V. and KISKA, T. and MUCHA, J. and SMÉKAL, Z. and KOŠŤÁLOVÁ, M. and REKTOROVÁ, I.",
  title="Non-invasive stimulation of the auditory feedback area for improved articulation in Parkinson's disease",
  journal="PARKINSONISM & RELATED DISORDERS",
  year="2019",
  volume="61",
  number="1",
  pages="187--192",
  doi="10.1016/j.parkreldis.2018.10.011",
  issn="1353-8020",
  url="https://www.sciencedirect.com/science/article/pii/S1353802018304395"
}