Detail publikace

Novel Vancomycin-Peptide Conjugate as Potent Antibacterial Agent against Vancomycin-Resistant Staphylococcus aureus

JELÍNKOVÁ, P. ŠPLÍCHAL, Z. JIMENEZ JIMENEZ, A. HADDAD, Y. MAZUMDAR, A. SUR, V. MILOSAVLJEVIĆ, V. KOPEL, P. BUCHTELOVÁ, H. GURÁŇ, R. ZÍTKA, O. RICHTERA, L. HEGEROVÁ, D. HEGER, Z. MOULICK, A. ADAM, V.

Originální název

Novel Vancomycin-Peptide Conjugate as Potent Antibacterial Agent against Vancomycin-Resistant Staphylococcus aureus

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Background: Increase in vancomycin (Van)-resistant bacterial strains including vancomycin-resistant Staphylococcus aureus (VRSA) and lack of new effective antibiotics have become a formidable health problem. Materials and methods: We designed a new conjugate composed of Van and a peptide Hecate (Hec; Van/Hec), and its potential antimicrobial activity was evaluated. Results: Results from disk diffusion test, time-kill assay, determination of minimum inhibitory concentration (MIC), microscopy, and comet assay showed strong antimicrobial effects of Van/Hec against wild-type, methicillin-resistant Staphylococcus aureus (MRSA) and VRSA. Microscopy revealed that the exposure to Van/Hec results in disruption of bacterial cell integrity in all tested strains, which was not observed in case of Van or Hec alone. Conclusion: Overall, we showed that the preparation of conjugates from antibiotics and biologically active peptides could help us to overcome the limitation of the use of antibiotic in the treatment of infections caused by multidrug-resistant bacteria.

Klíčová slova

Vancomycin; antibacterial; Staphylococcus aureus; antibiotic resistance; peptide

Autoři

JELÍNKOVÁ, P.; ŠPLÍCHAL, Z.; JIMENEZ JIMENEZ, A.; HADDAD, Y.; MAZUMDAR, A.; SUR, V.; MILOSAVLJEVIĆ, V.; KOPEL, P.; BUCHTELOVÁ, H.; GURÁŇ, R.; ZÍTKA, O.; RICHTERA, L.; HEGEROVÁ, D.; HEGER, Z.; MOULICK, A.; ADAM, V.

Vydáno

1. 11. 2018

Nakladatel

Dove Press

ISSN

1178-6973

Periodikum

Infection and Drug Resistance

Ročník

11

Číslo

1

Stát

Nový Zéland

Strany od

1807

Strany do

1817

Strany počet

11

URL

https://www.dovepress.com/novel-vancomycinndashpeptide-conjugate-as-potent-antibacterial-agent-a-peer-reviewed-article-IDR

Plný text v Digitální knihovně

http://hdl.handle.net/11012/137077

BibTex

@article{BUT151171,
  author="Pavlína {Jelínková} and Zbyněk {Šplíchal} and Ana Maria {Jimenez Jimenez} and Yazan Abdulmajeed Eyadh {Haddad} and Aninda {Mazumdar} and Vishma Pratap {Sur} and Vedran {Milosavljević} and Pavel {Kopel} and Hana {Michálková} and Roman {Guráň} and Ondřej {Zítka} and Lukáš {Richtera} and Dagmar {Hegerová} and Zbyněk {Heger} and Amitava {Moulick} and Vojtěch {Adam}",
  title="Novel Vancomycin-Peptide Conjugate as Potent Antibacterial Agent against Vancomycin-Resistant Staphylococcus aureus",
  journal="Infection and Drug Resistance",
  year="2018",
  volume="11",
  number="1",
  pages="1807--1817",
  doi="10.2147/IDR.S160975",
  issn="1178-6973",
  url="https://www.dovepress.com/novel-vancomycinndashpeptide-conjugate-as-potent-antibacterial-agent-a-peer-reviewed-article-IDR"
}