Detail publikace

Time-Efficient Perfusion Imaging Using DCE- and DSC-MRI

MACÍČEK, O. JIŘÍK, R. MIKULKA, J. BARTOŠ, M. ŠPRLÁKOVÁ, A. KEŘKOVSKÝ, M. STARČUK, Z. BARTUŠEK, K. TAXT, T.

Originální název

Time-Efficient Perfusion Imaging Using DCE- and DSC-MRI

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Dynamic contrast enhanced MRI (DCE-MRI) and dynamic susceptibility contrast MRI (DSC-MRI) are perfusion imaging techniques used mainly for clinical and preclinical measurement of vessel permeability and capillary blood flow, respectively. It is advantageous to apply both methods to exploit their complementary information about the perfusion status of the tissue. We propose a novel acquisition method that combines advantages of the current simultaneous and sequential acquisition. The proposed method consists of a DCE-MRI acquisition interrupted by DSC-MRI acquisition. A new method for processing of the DCE-MRI data is proposed which takes the interleaved acquisition into account. Analysis of both the DCE- and DSC-MRI data is reformulated so that they are approximated by the same pharmacokinetic model (constrained distributed capillary adiabatic tissue homogeneity model). This provides a straightforward evaluation of the methodology as some of the estimated DCE- and DSC-MRI perfusion parameters should be identical. Evaluation on synthetic data showed an acceptable precision and no apparent bias introduced by the interleaved character of the DCE-MRI acquisition. Intravascular perfusion parameters obtained from clinical glioma data showed a fairly high correlation of blood flow estimates from DCE- and DSC-MRI, however, an unknown scaling factor was still present mainly because of the tissue-specific r2* relaxivity. The results show validity of the proposed acquisition method. They also indicate that simultaneous processing of both DCE- and DSC-MRI data with joint estimation of some perfusion parameters (included in both DCE- and DSC-MRI) might be possible to increase the reliability of the DCE- and DSC-MRI methods alone.

Klíčová slova

Perfusion imaging; contrast agents; brain tumors; DCE-MRI; DSC-MRI

Autoři

MACÍČEK, O.; JIŘÍK, R.; MIKULKA, J.; BARTOŠ, M.; ŠPRLÁKOVÁ, A.; KEŘKOVSKÝ, M.; STARČUK, Z.; BARTUŠEK, K.; TAXT, T.

Vydáno

30. 11. 2018

Nakladatel

DE GRUYTER OPEN, Bogumiła Zuga 32A Str., 01-811 Warsaw, Poland

Místo

Warsaw, Poland

ISSN

1335-8871

Periodikum

Measurement Science Review

Ročník

18

Číslo

6

Stát

Slovenská republika

Strany od

262

Strany do

271

Strany počet

10

URL

http://www.degruyter.com/view/j/msr.2018.18.issue-6/msr-2018-0036/msr-2018-0036.xml?format=INT

BibTex

@article{BUT151243,
  author="Ondřej {Macíček} and Radovan {Jiřík} and Jan {Mikulka} and Michal {Bartoš} and Andrea {Šprláková} and Miloš {Keřkovský} and Zenon {Starčuk} and Karel {Bartušek} and Torfinn {Taxt}",
  title="Time-Efficient Perfusion Imaging Using DCE- and DSC-MRI",
  journal="Measurement Science Review",
  year="2018",
  volume="18",
  number="6",
  pages="262--271",
  doi="10.1515/msr-2018-0036",
  issn="1335-8871",
  url="http://www.degruyter.com/view/j/msr.2018.18.issue-6/msr-2018-0036/msr-2018-0036.xml?format=INT"
}