Detail publikace

Contrast-enhanced ultrasonography of the pancreas shows impaired perfusion in pancreas insufficient cystic fibrosis patients

ENGJOM, T. NYLUND, K. ERCHINGER, F. STANGELAND, M. LAERUM, B. MÉZL, M. JIŘÍK, R. GILJA, O. DIMCEVSKI, G.

Originální název

Contrast-enhanced ultrasonography of the pancreas shows impaired perfusion in pancreas insufficient cystic fibrosis patients

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Perfusion assessment of the pancreas is challenging and poorly evaluated. Pancreatic affection is a prevalent feature of cystic fibrosis (CF). Little is known about pancreatic perfusion in CF. We aimed to assess pancreatic perfusion by contrast-enhanced ultrasound (CEUS) analysed in the bolus-and-burst model and software. We performed contrast enhanced ultrasound of the pancreas in 25 CF patients and 20 healthy controls. Perfusion data was analysed using a dedicated perfusion model providing the mean capillary transit-time (MTT), blood flow (BF) and blood-volume (BV). CF patients were divided according to exocrine function. The pancreas insufficient CF patients had longer MTT (p ≤ 0.002), lower BF (p < 0.001) and lower BV (p < 0.05) compared to the healthy controls and sufficient CF patients. Interrater analysis showed substantial agreement for the analysis of mean transit time. The bolus-and-burst method used on pancreatic CEUS-examinations demonstrates reduced perfusion in CF patients with pancreas affection. The perfusion model and software requires further optimization and standardization to be clinical applicable for the assessment of pancreatic perfusion.

Klíčová slova

ultrasound perfusion imaging; cystic fibrosis; bolus & burst method, perfusion analysis

Autoři

ENGJOM, T.; NYLUND, K.; ERCHINGER, F.; STANGELAND, M.; LAERUM, B.; MÉZL, M.; JIŘÍK, R.; GILJA, O.; DIMCEVSKI, G.

Vydáno

15. 5. 2018

ISSN

1471-2342

Periodikum

BMC Medical Imaging

Ročník

18

Číslo

14

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

8

Strany počet

8

URL

http://link.springer.com/article/10.1186/s12880-018-0259-3

BibTex

@article{BUT151250,
  author="Trond {Engjom} and Kim {Nylund} and Friedemann {Erchinger} and Marcus {Stangeland} and Birger Norderud {Laerum} and Martin {Mézl} and Radovan {Jiřík} and Odd Helge {Gilja} and Georg {Dimcevski}",
  title="Contrast-enhanced ultrasonography of the pancreas shows impaired perfusion in pancreas insufficient cystic fibrosis patients",
  journal="BMC Medical Imaging",
  year="2018",
  volume="18",
  number="14",
  pages="1--8",
  doi="10.1186/s12880-018-0259-3",
  issn="1471-2342",
  url="http://link.springer.com/article/10.1186/s12880-018-0259-3"
}