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Detail publikace
HEUDE, E. TESAŘOVÁ, M. SEFTON, E. M. JULLIAN, E. ADACHI, N. GRIMALDI, A. ZIKMUND, T. KAISER, J. KARDON, G. KELLY, R. G. TAJBAKHSH, S.
Originální název
Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
In vertebrates, head and trunk muscles develop from different mesodermal populations and are regulated by distinct genetic networks. Neck muscles at the head-trunk interface remain poorly defined due to their complex morphogenesis and dual mesodermal origins. Here, we use genetically modified mice to establish a 3D model that integrates regulatory genes, cell populations and morphogenetic events that define this transition zone. We show that the evolutionary conserved cucullaris-derived muscles originate from posterior cardiopharyngeal mesoderm, not lateral plate mesoderm, and we define new boundaries for neural crest and mesodermal contributions to neck connective tissue. Furthermore, lineage studies and functional analysis of Tbx1- and Pax3-null mice reveal a unique developmental program for somitic neck muscles that is distinct from that of somitic trunk muscles. Our findings unveil the embryological and developmental requirements underlying tetrapod neck myogenesis and provide a blueprint to investigate how muscle subsets are selectively affected in some human myopathies.
Klíčová slova
cranial mesoderm, somite, neural crest, neck myogenesis
Autoři
HEUDE, E.; TESAŘOVÁ, M.; SEFTON, E. M.; JULLIAN, E.; ADACHI, N.; GRIMALDI, A.; ZIKMUND, T.; KAISER, J.; KARDON, G.; KELLY, R. G.; TAJBAKHSH, S.
Vydáno
19. 11. 2018
ISSN
2050-084X
Periodikum
eLife
Číslo
7
Stát
Spojené království Velké Británie a Severního Irska
Strany od
1
Strany do
26
Strany počet
URL
https://elifesciences.org/articles/40179
BibTex
@article{BUT151621, author="HEUDE, E. and TESAŘOVÁ, M. and SEFTON, E. M. and JULLIAN, E. and ADACHI, N. and GRIMALDI, A. and ZIKMUND, T. and KAISER, J. and KARDON, G. and KELLY, R. G. and TAJBAKHSH, S.", title="Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues", journal="eLife", year="2018", number="7", pages="1--26", doi="10.7554/eLife.40179", issn="2050-084X", url="https://elifesciences.org/articles/40179" }