Detail publikace

STRENGTH DEGRADATION OF CALCIUM PHOSPHATE SCAFFOLDS UNDER CONDITIONS SIMULATING OSTEOCLASTIC RESORPTION

ŠŤASTNÝ, P. TRUNEC, M. SEDLÁČEK, R.

Originální název

STRENGTH DEGRADATION OF CALCIUM PHOSPHATE SCAFFOLDS UNDER CONDITIONS SIMULATING OSTEOCLASTIC RESORPTION

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

Calcium phosphates (CaPs) ceramics are the first-choice material for large bone defect healing. Scaffolds prepared from CaPs must fulfill many demands. One of these demands is bioresorbability of the scaffold material. In case of sintered ceramic scaffolds the only degradation mechanism (at least at the beginning of the resorption) is acidic mechanism mediated by osteoclasts. This degradation leads inevitably to the loss of mechanical strength. The loss of mechanical strength should be continual and match the growth of the new bone tissue. Within the scope of our research we present results of the mechanical strength degradation of the three types of highly porous CaPs scaffolds. Hydroxyapatite (HA), tricalcium phosphate (TCP) and biphasic calcium phosphate (BCP) scaffolds with similar porosity (over 80%) and pore size were tested. Samples were exposed to slightly acidic environment of the McIlvaine buffer (pH 5.5) at a temperature of 37 °C. Strength degradation, phase and morphological changes were evaluated at 0, 2, 7, and 14 days of exposition. Mechanical characteristics of the samples were tested in compression mode. BCP material showed promising behavior of step-by-step strength degradation with reasonable strength of 0.55 MPa after 14 days. Degradation of TCP material was very fast and reasonable mechanical strength was lost after just two days of the exposition to the acidic environment. Final strength of TCP scaffold was 0.1 MPa. Strength of the HA scaffolds were almost preserved and only very limited degradation took place with final strength reaching over 1 MPa. Mechanisms of the degradation of different CaP scaffolds in the acidic environment were investigated and discussed. The results show a superiority of BCP material as potential material for degradable bone scaffolds with good strength stability. These results were supported by biological testing of the samples. BCP samples provided the best environment for cell attachment and their proliferation in vitro. These results will be utilized for preparation of the biodegradable bone scaffold for spinal fusion surgery.

Klíčová slova

ceramic bio-scaffolds, degradation, mechanical testing

Autoři

ŠŤASTNÝ, P.; TRUNEC, M.; SEDLÁČEK, R.

Vydáno

26. 11. 2018

Nakladatel

Editrice La Mandragora s.r.l

Místo

Bologna

ISBN

978-88-7586-599-3

Kniha

Proceedings of the workshop for young ceramists

Strany od

49

Strany do

52

Strany počet

146

BibTex

@misc{BUT151971,
  author="Přemysl {Šťastný} and Martin {Trunec} and Radek {Sedláček}",
  title="STRENGTH DEGRADATION OF CALCIUM PHOSPHATE SCAFFOLDS UNDER CONDITIONS SIMULATING OSTEOCLASTIC RESORPTION",
  booktitle="Proceedings of the workshop for young ceramists",
  year="2018",
  pages="49--52",
  publisher="Editrice La Mandragora s.r.l",
  address="Bologna",
  isbn="978-88-7586-599-3",
  note="abstract"
}