Detail publikace

Synthesis and structural characterization of antimicrobial binuclear copper (II) coordination compounds bridged by hydroxy- and/or thiodipropionic acid

BUCHTELOVÁ, H. ŠKUBALOVÁ, Z. STRMISKA, V. MICHÁLEK, P. KOČIOVÁ, S. ŠMERKOVÁ, K. KRUSZYŃSKI, R. BIEŃKO, A. KAJ, M. LEWINSKA, A. BIEŃKO, D. MALIK-GAJEWSKA, M. MILOSAVLJEVIĆ, V. KOPEL, P. HEGER, Z. ADAM, V.

Originální název

Synthesis and structural characterization of antimicrobial binuclear copper (II) coordination compounds bridged by hydroxy- and/or thiodipropionic acid

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

In the present study, two binuclear copper(II) coordination compounds bridged by hydroxy- and thiodipropionic acid have been synthesized. The structure of compounds was determined by X-ray crystallography. The central copper atoms exist in square pyramidal surroundings. Basal plane is formed by nitrogen atoms of amines and oxygen atoms of bridges, whereas apical positions are occupied by oxygen atoms of coordinated water molecules. Temperature dependence study of magnetic susceptibility proved strong antiferromagnetic exchange between copper atoms in hydroxy-bridged complex. These coordination compounds were also tested for their biological activities in vitro. Both coordination compounds exhibit pronounced cytocompatibility in mammalian epithelial cells with no induction of oxidative stress and DNA fragmentation. Moreover, synthesized compounds are hemocompatible and do not alter expression of a marker of multiple cellular stress, p53. On the other hand, both compounds had stimulatory effect on expression of metallothioneins (MT-1/2 and MT-3). Antimicrobial testing on Escherichia colt, Staphylococcus aureus and methicillin-resistant Staphylococcus aureus revealed that both copper compounds exhibit antibacterial activity regardless the cell wall composition. Overall, current work presents a synthesis of Cu(II) coordination compounds with interesting biological behavior and with a promising potential to be further tested in pre-clinical models.

Klíčová slova

Antimicrobial agents; Biocompatibility; Copper coordination compounds; Methicillin-resistant Staphylococcus aureus; Magnetic properties

Autoři

BUCHTELOVÁ, H.; ŠKUBALOVÁ, Z.; STRMISKA, V.; MICHÁLEK, P.; KOČIOVÁ, S.; ŠMERKOVÁ, K.; KRUSZYŃSKI, R.; BIEŃKO, A.; KAJ, M.; LEWINSKA, A.; BIEŃKO, D.; MALIK-GAJEWSKA, M.; MILOSAVLJEVIĆ, V.; KOPEL, P.; HEGER, Z.; ADAM, V.

Vydáno

28. 2. 2019

ISSN

0162-0134

Periodikum

JOURNAL OF INORGANIC BIOCHEMISTRY

Ročník

191

Číslo

1

Stát

Spojené státy americké

Strany od

8

Strany do

20

Strany počet

13

BibTex

@article{BUT156201,
  author="Hana {Michálková} and Zuzana {Škubalová} and Vladislav {Strmiska} and Petr {Michálek} and Silvia {Kočiová} and Kristýna {Šmerková} and Rafał {Kruszyński} and Alina {Bieńko} and Michalina {Kaj} and Agnieszka {Lewinska} and Dariusz {Bieńko} and Magdalena {Malik-Gajewska} and Vedran {Milosavljević} and Pavel {Kopel} and Zbyněk {Heger} and Vojtěch {Adam}",
  title="Synthesis and structural characterization of antimicrobial binuclear copper (II) coordination compounds bridged by hydroxy- and/or thiodipropionic acid",
  journal="JOURNAL OF INORGANIC BIOCHEMISTRY",
  year="2019",
  volume="191",
  number="1",
  pages="8--20",
  doi="10.1016/j.jinorgbio.2018.10.011",
  issn="0162-0134"
}