Detail publikace

Prospects of pulsed amperometric detection in flow-based analytical systems - A review

ISLAM, M. MAHBUB, P. NESTERENKO, P. PAULL, B. MACKA, M.

Originální název

Prospects of pulsed amperometric detection in flow-based analytical systems - A review

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Electrochemical (EC) detection techniques in flow-based analytical systems such as flow injection analysis (FIA), capillary electrophoresis (CE), and liquid chromatography (LC) have attracted continuous interest over the last three decades, leading to significant advances in EC detection of a wide range of analytes in the liquid phase. In this context, the unique advantages of pulsed amperometric detection (PAD) in terms of high sensitivity and selectivity, and electrode cleaning through the application of pulsed potential for noble metal electrodes (e.g. Au, Pt), have established PAD as an important detection technique for a variety of electrochemically active compounds. PAD is especially valuable for analytes not detectable by ultraviolet (UV) photometric detection, such as organic aliphatic compounds and carbohydrates, especially when used with miniaturised capillary and chip-based separation methods. These applications have been accomplished through advances in PAD potential waveform design, as well as through the incorporation of nanomaterials (NMs) employed as microelectrodes in PAD. PAD allows online pulsed potential cleaning and coupling with capillary or standard separation techniques. The NMs are largely employed in microelectrodes to speed up mass and electron transfer between electrode surfaces and to perform as reactants in EC analysis. These advances in PAD have improved the sensitive and selective EC detection of analytes, especially in biological samples with complex sample matrices, and detection of electro-inactive compounds such as aliphatic organic compounds (i.e., formic acid, acetic acid, maleic acids, and beta-cyclodextrin complexes). This review addresses the fundamentals of PAD, the role of pulsed sequences in AD, the utilisation of different EC detectors for PAD, technological advancements in PAD waveforms, utilisation of microelectrodes in PAD techniques, advances in the use of NMs in PAD, the applications of PAD, and prospects for EC detection, with emphasis on PAD in flow-based systems.

Klíčová slova

Electrochemical detector; Flow-based analytical systems; Pulsed amperometric detection

Autoři

ISLAM, M.; MAHBUB, P.; NESTERENKO, P.; PAULL, B.; MACKA, M.

Vydáno

4. 4. 2019

ISSN

0003-2670

Periodikum

ANALYTICA CHIMICA ACTA

Ročník

1052

Číslo

1

Stát

Nizozemsko

Strany od

10

Strany do

26

Strany počet

17

BibTex

@article{BUT156207,
  author="Muhammed Ariful {Islam} and Parvez {Mahbub} and Pavel {Nesterenko} and Brett {Paull} and Miroslav {Macka}",
  title="Prospects of pulsed amperometric detection in flow-based analytical systems - A review",
  journal="ANALYTICA CHIMICA ACTA",
  year="2019",
  volume="1052",
  number="1",
  pages="10--26",
  doi="10.1016/j.aca.2018.10.066",
  issn="0003-2670"
}