Detail publikace

Simulation of Airway Deposition of an Aerosol Drug in COPD Patients

FARKAS, Á. LÍZAL, F. JEDELSKÝ, J. ELCNER, J. HORVÁTH, A. JÍCHA, M.

Originální název

Simulation of Airway Deposition of an Aerosol Drug in COPD Patients

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Medical aerosols are key elements of current chronic obstructive pulmonary disease (COPD) therapy. Therapeutic effects are conditioned by the delivery of the right amount of medication to the right place within the airways, that is, to the drug receptors. Deposition of the inhaled drugs is sensitive to the breathing pattern of the patients which is also connected with the patient's disease severity. The objective of this work was to measure the realistic inhalation profiles of mild, moderate, and severe COPD patients, simulate the deposition patterns of Symbicort((R)) Turbuhaler((R)) dry powder drug and compare them to similar patterns of healthy control subjects. For this purpose, a stochastic airway deposition model has been applied. Our results revealed that the amount of drug depositing within the lungs correlated with the degree of disease severity. While drug deposition fraction in the lungs of mild COPD patients compared with that of healthy subjects (28% versus 31%), lung deposition fraction characteristic of severe COPD patients was lower by a factor of almost two (about 17%). Deposition fraction of moderate COPD patients was in-between (23%). This implies that for the same inhaler dosage severe COPD patients receive a significantly lower lung dose, although, they would need more.

Klíčová slova

aerosol drug deposition; inhalation profile measurements; dry powder inhalers

Autoři

FARKAS, Á.; LÍZAL, F.; JEDELSKÝ, J.; ELCNER, J.; HORVÁTH, A.; JÍCHA, M.

Vydáno

1. 4. 2019

Nakladatel

MDPI

ISSN

1999-4923

Periodikum

Pharmaceutics

Ročník

11

Číslo

4

Stát

Švýcarská konfederace

Strany od

1

Strany do

10

Strany počet

10

URL

https://www.mdpi.com/1999-4923/11/4/153

Plný text v Digitální knihovně

http://hdl.handle.net/11012/156796

BibTex

@article{BUT156512,
  author="Árpád {Farkas} and František {Lízal} and Jan {Jedelský} and Jakub {Elcner} and Alpár {Horváth} and Miroslav {Jícha}",
  title="Simulation of Airway Deposition of an Aerosol Drug in COPD Patients",
  journal="Pharmaceutics",
  year="2019",
  volume="11",
  number="4",
  pages="1--10",
  doi="10.3390/pharmaceutics11040153",
  issn="1999-4923",
  url="https://www.mdpi.com/1999-4923/11/4/153"
}