Detail publikace

Drug Release Kinetics of Electrospun PHB Meshes

KUNDRÁT, V. ČERNEKOVÁ, N. KOVALČÍK, A. ENEV, V. MÁROVÁ, I.

Originální název

Drug Release Kinetics of Electrospun PHB Meshes

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Microbial poly(3-hydroxybutyrate) (PHB) has several advantages including its biocompatibility and ability to degrade in vivo and in vitro without toxic substances. This paper investigates the feasibility of electrospun PHB meshes serving as drug delivery systems. The morphology of the electrospun samples was modified by varying the concentration of PHB in solution and the solvent composition. Scanning electron microscopy of the electrospun PHB scaffolds revealed the formation of different morphologies including porous, filamentous/beaded and fiber structures. Levofloxacin was used as the model drug for incorporation into PHB electrospun meshes. The entrapment efficiency was found to be dependent on the viscosity of the PHB solution used for electrospinning and ranged from 14.4–81.8%. The incorporation of levofloxacin in electrospun meshes was confirmed by Fourier-transform infrared spectroscopy and UV-VIS spectroscopy. The effect of the morphology of the electrospun meshes on the levofloxacin release profile was screened in vitro in phosphate-buffered saline solution. Depending upon the morphology, the electrospun meshes released about 14–20% of levofloxacin during the first 24 h. The percentage of drug released after 13 days increased up to 32.4% and was similar for all tested morphologies. The antimicrobial efficiency of all tested samples independent of the morphology, was confirmed by agar diffusion testing.

Klíčová slova

biomaterials; electrospinning; drug release kinetics; levofloxacin; morphology; poly(3-hydroxybutyrate); scaffolds

Autoři

KUNDRÁT, V.; ČERNEKOVÁ, N.; KOVALČÍK, A.; ENEV, V.; MÁROVÁ, I.

Vydáno

14. 6. 2019

Nakladatel

MDPI

ISSN

1996-1944

Periodikum

Materials

Ročník

12

Číslo

12

Stát

Švýcarská konfederace

Strany od

1

Strany do

13

Strany počet

13

URL

https://www.mdpi.com/1996-1944/12/12/1924

Plný text v Digitální knihovně

http://hdl.handle.net/11012/181097

BibTex

@article{BUT157318,
  author="Vojtěch {Kundrát} and Nicole {Černeková} and Adriána {Kovalčík} and Vojtěch {Enev} and Ivana {Márová}",
  title="Drug Release Kinetics of Electrospun PHB Meshes",
  journal="Materials",
  year="2019",
  volume="12",
  number="12",
  pages="1--13",
  doi="10.3390/ma12121924",
  issn="1996-1944",
  url="https://www.mdpi.com/1996-1944/12/12/1924"
}

Dokumenty

materials-12-01924.pdf