Detail publikace

Genetic and Developmental Basis of Facial Individuality

KAUCKÁ, M. TESAŘOVÁ, M. ZIKMUND, T. KAISER, J. ADAMEYKO, I.

Originální název

Genetic and Developmental Basis of Facial Individuality

Typ

prezentace, poster

Jazyk

angličtina

Originální abstrakt

There is a remarkable variety of facial shapes in the animal kingdom that enables a broad spectrum of functions and various skills. In addition to the obvious functional aspects such as protection of the central nervous system and the sensitive sensory organs, feeding as well as providing points for muscle attachment, the facial shape is important in many more ways. For example, humans use facial individuality for mutual recognition that assists social interaction, communication and affects numerous important aspects of everyday life. Pathological conditions include a wide spectrum of deficiencies, and may involve eating, breathing and speech impairments, and in some species, emotional problems and low quality of life in general. The facial features reflect the underlying geometry of skeletal structures. Two types of stiff tissue, cartilage and bone, represent the craniofacial internal skeleton. Bone is predominantly derived from pre-shaped cartilaginous templates that are formed during the embryonic development. The first facial shapes are represented by forming mesenchymal condensations. The induction of a mesenchymal condensation in a specific location is instructed by signals coming from various sources, for instance from parts of the developing brain and olfactory epithelium. Enhancers influence the levels of these signals and this regulation may represent the genetic basis of facial individuality. Condensations turn into the cartilage that later expands tremendously while maintaining the perfect established 3D-shape. The control of the shape and size during the whole embryonic growth of the mammalian face is based on uncoupled mechanisms of transverse integration of clonal columns of chondrocytes, control of the cartilage thickness, and existence of growth zones. Supplementary shape fine-tuning is later achieved by additionalwaves of mesenchymal condensations.

Klíčová slova

Conference talk

Autoři

KAUCKÁ, M.; TESAŘOVÁ, M.; ZIKMUND, T.; KAISER, J.; ADAMEYKO, I.

Vydáno

3. 6. 2019

Nakladatel

Wiley

ISSN

0362-2525

Periodikum

JOURNAL OF MORPHOLOGY

Ročník

280

Stát

Spojené státy americké

Strany od

10

Strany do

11

Strany počet

244

URL

https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003

BibTex

@misc{BUT157860,
  author="Markéta {Kaucká} and Markéta {Kaiser} and Tomáš {Zikmund} and Jozef {Kaiser} and Igor {Adameyko}",
  title="Genetic and Developmental Basis of Facial Individuality",
  year="2019",
  journal="JOURNAL OF MORPHOLOGY",
  volume="280",
  pages="10--11",
  publisher="Wiley",
  issn="0362-2525",
  url="https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003",
  note="presentation, poster"
}