Detail publikace

Bioeconomic polyhydroxyalkanoate (PHA) manufacturing, and factors boosting PHA biosynthesis

KOLLER, M. OBRUČA, S. BRAUNEGG, G.

Originální název

Bioeconomic polyhydroxyalkanoate (PHA) manufacturing, and factors boosting PHA biosynthesis

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

Several steps of the process chain to biosynthesize microbialpolyhydroxyalkanoate (PHA) biopolyesters need to be consideredin order to make these auspicious biopolyesters quantitatively andqualitatively competitive on the global plastic market. Selection,adaptation and genetic modification of microbial strains, feedstocksupply, bioreactor design and process regime, and product recov-ery require optimization. Especially the application of robust, fastgrowing and highly productive microbial species for PHA pro-duction using inexpensive carbon-rich feedstocks has become afrequently used strategy towards economically feasible PHA pro-duction. During biosynthesis, exogenous stress factors triggeringPHA accumulation in microbial biomass play a still underestimatedrole. As recently revealed, presence of PHA helps cells to mitigatethe harmful effects of diverse stress factors like osmotic imbal-ance, oxidative challenge or UV-radiation; biotechnologically, onecan deliberately expose bacterial cells to such stress conditions toboost intracellular PHA biosynthesis. From the engineering per-spective, new bioreactors and continuous operation mode increasePHA productivity and customize PHA’s properties. Together withthe application of sustainable techniques to recover PHA frommicrobial biomass, such as using recyclable and eco-friendly sol-vents under extreme extraction conditions, PHA manufacturingcan be configured as entirely green and sustainable bioeconomictechnology.

Klíčová slova

polyhydroxyalkanoates; bio-economics; bacteria

Autoři

KOLLER, M.; OBRUČA, S.; BRAUNEGG, G.

Vydáno

1. 11. 2019

Nakladatel

Elsevier

ISSN

1873-4863

Periodikum

JOURNAL OF BIOTECHNOLOGY

Ročník

305

Stát

Nizozemsko

Strany od

4

Strany do

4

Strany počet

1

URL

https://reader.elsevier.com/reader/sd/pii/S0168165619301920?token=6C29D68B18EB12E6623BF0303ABD915EB3654003F439A36604C39FBE512E5ED115DDF4DD17D75EBF1078F47C0023EE9D

BibTex

@misc{BUT163454,
  author="KOLLER, M. and OBRUČA, S. and BRAUNEGG, G.",
  title="Bioeconomic polyhydroxyalkanoate (PHA) manufacturing, and factors boosting PHA biosynthesis",
  year="2019",
  journal="JOURNAL OF BIOTECHNOLOGY",
  volume="305",
  pages="4--4",
  publisher="Elsevier",
  doi="10.1016/j.jbiotec.2019.05.028",
  issn="1873-4863",
  url="https://reader.elsevier.com/reader/sd/pii/S0168165619301920?token=6C29D68B18EB12E6623BF0303ABD915EB3654003F439A36604C39FBE512E5ED115DDF4DD17D75EBF1078F47C0023EE9D",
  note="abstract"
}