Detail publikace

Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells

KONG, L. ROSLI, N. CHIA, H. GUAN, J. PUMERA, M.

Originální název

Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Magnesium (Mg)-based micromotors have attracted considerable attention as they are capable of moving in water and human blood plasma without external fuels. It has also been demonstrated that they have potential for drug delivery in mouse stomach. However, their biocompatibility and cytotoxicity to human cells have yet to be studied. Therefore, we performed cytotoxicity study of Mg/Pt Janus micromotors with human lung carcinoma epithelial cells (A549), human breast cancer cells (MCF-7), human embryonic kidney cells (HEK-293), human liver carcinoma cells (HepG2) and human cervical cancer cells (HeLa). The highest concentration of micromotors tested, 200 mu g mL(-1), drastically induced a high toxic effect on the cells and reduced the cell viability to below 60%. This shows while Pt/Au nanomachines were found to be safe previously, this is not the case of the Mg/Pt micromachines.

Klíčová slova

Cytotoxicity; Micromotors; Human cells

Autoři

KONG, L.; ROSLI, N.; CHIA, H.; GUAN, J.; PUMERA, M.

Vydáno

1. 10. 2019

Nakladatel

CHEMICAL SOC JAPAN

Místo

TOKYO

ISSN

0009-2673

Periodikum

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Ročník

92

Číslo

10

Stát

Japonsko

Strany od

1754

Strany do

1758

Strany počet

5

URL

https://www.journal.csj.jp/doi/10.1246/bcsj.20190104

BibTex

@article{BUT163619,
  author="Lei {Kong} and Nur Farhanah {Rosli} and Hui Ling {Chia} and Jianguo {Guan} and Martin {Pumera}",
  title="Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells",
  journal="BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN",
  year="2019",
  volume="92",
  number="10",
  pages="1754--1758",
  doi="10.1246/bcsj.20190104",
  issn="0009-2673",
  url="https://www.journal.csj.jp/doi/10.1246/bcsj.20190104"
}