Detail publikace

Comparison of Different Approaches to Surface Functionalization of Biodegradable Polycaprolactone Scaffolds

PERMYAKOVA, E. KIRYUKHANTSEV-KORNEEV, P. GUDZ, K. KONOPATSKY, A. POLČÁK, J. ZHITNYAK, I. GLOUSHANKOVA, N. SHTANSKY, D. MANAKHOV, A.

Originální název

Comparison of Different Approaches to Surface Functionalization of Biodegradable Polycaprolactone Scaffolds

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Due to their good mechanical stability compared to gelatin, collagen or polyethylene glycol nanofibers and slow degradation rate, biodegradable poly-epsilon-caprolactone (PCL) nanofibers are promising material as scaffolds for bone and soft-tissue engineering. Here, PCL nanofibers were prepared by the electrospinning method and then subjected to surface functionalization aimed at improving their biocompatibility and bioactivity. For surface modification, two approaches were used: (i) COOH-containing polymer was deposited on the PCL surface using atmospheric pressure plasma copolymerization of CO2 and C2H4, and (ii) PCL nanofibers were coated with multifunctional bioactive nanostructured TiCaPCON film by magnetron sputtering of TiC-CaO-Ti3POx target. To evaluate bone regeneration ability in vitro, the surface-modified PCL nanofibers were immersed in simulated body fluid (SBF, 1x) for 21 days. The results obtained indicate different osteoblastic and epithelial cell response depending on the modification method. The TiCaPCON-coated PCL nanofibers exhibited enhanced adhesion and proliferation of MC3T3-E1 cells, promoted the formation of Ca-based mineralized layer in SBF and, therefore, can be considered as promising material for bone tissue regeneration. The PCL-COOH nanofibers demonstrated improved adhesion and proliferation of IAR-2 cells, which shows their high potential for skin reparation and wound dressing.

Klíčová slova

tissue engineering; polycaprolactone nanofibers; plasma modification; mineralization; XPS

Autoři

PERMYAKOVA, E.; KIRYUKHANTSEV-KORNEEV, P.; GUDZ, K.; KONOPATSKY, A.; POLČÁK, J.; ZHITNYAK, I.; GLOUSHANKOVA, N.; SHTANSKY, D.; MANAKHOV, A.

Vydáno

1. 12. 2019

Nakladatel

MDPI

Místo

BASEL

ISSN

2079-4991

Periodikum

Nanomaterials

Ročník

9

Číslo

12

Stát

Švýcarská konfederace

Strany od

1

Strany do

16

Strany počet

16

URL

https://www.mdpi.com/2079-4991/9/12/1769

Plný text v Digitální knihovně

http://hdl.handle.net/11012/189002

BibTex

@article{BUT163624,
  author="Elizaveta {Permyakova} and Philip {Kiryukhantsev-Korneev} and Kristina Yu. {Gudz} and Anton S. {Konopatsky} and Josef {Polčák} and I.Y. {Zhitnyak} and Natalia A. {Gloushankova} and Dmitry V. {Shtansky} and Anton {Manakhov}",
  title="Comparison of Different Approaches to Surface Functionalization of Biodegradable Polycaprolactone Scaffolds",
  journal="Nanomaterials",
  year="2019",
  volume="9",
  number="12",
  pages="1--16",
  doi="10.3390/nano9121769",
  issn="2079-4991",
  url="https://www.mdpi.com/2079-4991/9/12/1769"
}