Detail publikace

Mass Spectrometry of Heavy Analytes and Large Biological Aggregates by Monitoring Changes in the Quality Factor of Nanomechanical Resonators in Air

STACHIV, I. GAN, L. KUO, CH.Y. ŠITTNER, P. ŠEVEČEK, O.

Originální název

Mass Spectrometry of Heavy Analytes and Large Biological Aggregates by Monitoring Changes in the Quality Factor of Nanomechanical Resonators in Air

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Nanomechanical resonators are routinely used for identification of various analytes like biological and chemical molecules, viruses or bacteria cells from the frequency response. This identification based on the multimode frequency shift measurement is limited to analyte of mass that is much lighter than the resonator mass; hence the analyte can be modeled as a point particle and, as such, its stiffness and nontrivial binding effects like surface stress can be neglected. For heavy analytes (> MDa) this identification, however, leads to incorrectly estimated masses. Here, by using a well-known frequency response of the nanomechanical resonator in air, we show that the heavy analyte can be identified without a need for highly challenging analysis of the analyte position, stiffness and/or binding effects just by monitoring changes in quality factor of a single harmonic frequency. Theory with a detailed procedure of mass extraction from quality factor is developed. In air, the quality factor depends on analyte mass and known air damping, while impact of the intrinsic dissipation is negligibly small. We find that the highest mass sensitivity (for considered resonator dimensions ~zg) can be achieved for rarely measured lateral mode, whereas the commonly detected flexural mode yields the lowest sensitivity. Validity of proposed procedure is confirmed by extracting mass of heavy analytes (GDa) made of protein and E. coli bacteria cells, and the ragweed pollen nanoparticle adsorbed on surface of the nanomechanical resonator(s) in air, of which the required changes in quality factor were previously experimentally measured, and by using numerical simulations. Our results open a doorway for rapid detection of viruses and bacteria cells using standard nanomechanical mass sensors.

Klíčová slova

mass spectrometry; mass sensor; NEMS; nanomechanical resonator; nanomechanics

Autoři

STACHIV, I.; GAN, L.; KUO, CH.Y.; ŠITTNER, P.; ŠEVEČEK, O.

Vydáno

19. 6. 2020

Nakladatel

ACS Publications

Místo

Spojené státy americké

ISSN

2379-3694

Periodikum

ACS Sensors

Ročník

5

Číslo

7

Stát

Spojené státy americké

Strany od

2128

Strany do

2135

Strany počet

8

URL

https://pubs.acs.org/doi/10.1021/acssensors.0c00756

BibTex

@article{BUT164671,
  author="STACHIV, I. and GAN, L. and KUO, CH.Y. and ŠITTNER, P. and ŠEVEČEK, O.",
  title="Mass Spectrometry of Heavy Analytes and Large Biological Aggregates by Monitoring Changes in the Quality Factor of Nanomechanical Resonators in Air",
  journal="ACS Sensors",
  year="2020",
  volume="5",
  number="7",
  pages="2128--2135",
  doi="10.1021/acssensors.0c00756",
  issn="2379-3694",
  url="https://pubs.acs.org/doi/10.1021/acssensors.0c00756"
}