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VELCER, T. PEKAŘ, M.
Originální název
Micellar nanocarriers based on hydrophobical hyaluronan
Typ
abstrakt
Jazyk
angličtina
Originální abstrakt
This work studies the properties of modified biopolymers for potential use in targeted drug delivery. Various samples of hydrophobically modified hyaluronan with different degree of substitution were selected. The critical aggregation concentration (CAC) of these samples was measured using fluorescence spectroscopy, wherein it was found that micelle formation occurs over a wide concentration region. Environment of 0.15 M NaCl causes the decrease of CAC only slightly or not at all. The results were confirmed by measuring the dynamic light scattering, which also showed an increase in the size of aggregates with an increasing concentration. One of the samples exhibited a double size distribution. Zeta potential measurements provide information about stability of the samples. The results of this study confirm that the studied samples seem to be a suitable candidates for the post of drug carrier for targeted delivery.
Klíčová slova
hydrophobically modified hyaluronan, fluorescence spectroscopy, dynamic light scattering
Autoři
VELCER, T.; PEKAŘ, M.
Vydáno
16. 10. 2019
Nakladatel
TANGER Ltd.
Místo
Ostrava, CZ
ISBN
978-80-87294-94-9
Kniha
NANOCON 2019 - Abstracts
Edice
1.
Strany od
123
Strany do
Strany počet
1
BibTex
@misc{BUT165641, author="Tomáš {Velcer} and Miloslav {Pekař}", title="Micellar nanocarriers based on hydrophobical hyaluronan", booktitle="NANOCON 2019 - Abstracts", year="2019", series="1.", pages="123--123", publisher="TANGER Ltd.", address="Ostrava, CZ", isbn="978-80-87294-94-9", note="abstract" }