Detail publikace

Moderate thickness of lipid core in shoulder region of atherosclerotic plaque determines vulnerable plaque - A parametric study

POLZER, S. POLIŠENSKÁ, A. NOVÁK, K. BURŠA, J.

Originální název

Moderate thickness of lipid core in shoulder region of atherosclerotic plaque determines vulnerable plaque - A parametric study

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Peak stress in the fibrous cap of atherosclerotic plaque is largely determined by the cap thickness which cannot be accurately estimated in vivo. This parametric study investigates idealized atherosclerotic plaque geometries. Finite element modeling is applied to search for larger morphological features associated with high cap stresses. By varying seven geometrical and two loading parameters, 100 3D model geometries of atherosclerotic plaques in common iliac artery were generated. In each model peak cap stress was cal- culated, and statistical comparison of the geometries generating the highest and lowest peak cap stresses was performed. The analysis showed that, compared to geometries generating the lowest stresses, those with high peak cap stress had a significantly lower cap thickness, higher stenosis ratio, lower relative lipid core volume, and cap shoulder radius larger than lipid core radius. High cap stress was observed for cap thicknesses up to 0.13 mm. It can be concluded that vulnerable plaques contain thin fibrous cap, large stenosis ratio and only moderate small-radius lipid core which reaches the shoulder region of the fibrous cap. (C) 2019 IPEM. Published by Elsevier Ltd. All rights reserved.

Klíčová slova

Atherosclerotic plaque, Finite element analysis, Parametric study

Autoři

POLZER, S.; POLIŠENSKÁ, A.; NOVÁK, K.; BURŠA, J.

Vydáno

29. 7. 2019

Nakladatel

Elsevier

ISSN

1350-4533

Periodikum

MEDICAL ENGINEERING & PHYSICS

Ročník

69

Číslo

7

Stát

Spojené království Velké Británie a Severního Irska

Strany od

140

Strany do

146

Strany počet

7

URL

https://www.sciencedirect.com/science/article/pii/S1350453319300876?via%3Dihub

BibTex

@article{BUT165765,
  author="Stanislav {Polzer} and Anna {Polišenská} and Kamil {Novák} and Jiří {Burša}",
  title="Moderate thickness of lipid core in shoulder region of atherosclerotic plaque determines vulnerable plaque - A parametric study",
  journal="MEDICAL ENGINEERING & PHYSICS",
  year="2019",
  volume="69",
  number="7",
  pages="140--146",
  doi="10.1016/j.medengphy.2019.04.011",
  issn="1350-4533",
  url="https://www.sciencedirect.com/science/article/pii/S1350453319300876?via%3Dihub"
}