Detail publikace

Predicting the Angle of Internal Friction from Simple Dynamic Consolidation Using Lactose Grades as Model

TRPĚLKOVÁ, Ž. HURYCHOVÁ, H. ONDREJČEK, P. SVĚRÁK, T. KUENTZ, M. ŠKLUBALOVÁ, Z.

Originální název

Predicting the Angle of Internal Friction from Simple Dynamic Consolidation Using Lactose Grades as Model

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Purpose Powder flow and packing behavior are among other factors determined by particle friction, which is traditionally measured in shear cells as the angle of internal friction (AIF). Considering that an AIF at a normal stress should be comparable to friction during tapping consolidation, this work aims at whether dynamic consolidation under gravity can be used to estimate an AIF. Methods Powder consolidation by controlled tapping was studied for seven commercially available types of lactose. A porosity factor was determined, and values were compared with the AIF obtained from Jenike shear cell measurements. Results Plotting porosity factor vs. number of applied taps provided an estimated angle of internal friction (AIF(E)) that was obtained from the slope of a linear relationship. A significant linear correlation (r = 0.825;p = 0.0223) was evidenced between AIF(E)and those AIF(J)estimated from linearized yield locus measurements of using the Jenike shear cell. Conclusions The good linear correlation between the angle of internal friction estimated from dynamic powder consolidation and the internal friction obtained by a shear cell is of high practical relevance. The latter shear cell behavior is only occasionally studied in the pharmaceutical industry, whereas dynamic powder tapping is a standard analysis.

Klíčová slova

Powders; Consolidation; Angle of internal friction; Jenike shear tester; Tapping

Autoři

TRPĚLKOVÁ, Ž.; HURYCHOVÁ, H.; ONDREJČEK, P.; SVĚRÁK, T.; KUENTZ, M.; ŠKLUBALOVÁ, Z.

Vydáno

1. 9. 2020

Nakladatel

SPRINGER

Místo

NEW YORK

ISSN

1872-5120

Periodikum

Journal of Pharmaceutical Innovation

Ročník

15

Číslo

3

Stát

Spojené státy americké

Strany od

380

Strany do

391

Strany počet

12

URL

https://link.springer.com/article/10.1007%2Fs12247-019-09387-3

BibTex

@article{BUT169818,
  author="TRPĚLKOVÁ, Ž. and HURYCHOVÁ, H. and ONDREJČEK, P. and SVĚRÁK, T. and KUENTZ, M. and ŠKLUBALOVÁ, Z.",
  title="Predicting the Angle of Internal Friction from Simple Dynamic Consolidation Using Lactose Grades as Model",
  journal="Journal of Pharmaceutical Innovation",
  year="2020",
  volume="15",
  number="3",
  pages="380--391",
  doi="10.1007/s12247-019-09387-3",
  issn="1872-5120",
  url="https://link.springer.com/article/10.1007%2Fs12247-019-09387-3"
}