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WANG, L. GAO, W. NG, S. PUMERA, M.
Originální název
Chiral Protein-Covalent Organic Framework 3D-Printed Structures as Chiral Biosensors
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Three-dimensional (3D) printing technology has attracted great attention for prototyping different electrochemical sensor devices. However, chiral recognition remains a crucial challenge for electrochemical sensors with similar physicochemical properties such as enantiomers. In this work, a magnetic covalent organic framework (COF) and bovine serum albumin (BSA) (as the chiral surface) functionalized 3D-printed electrochemical chiral sensor is reported for the first time. The characterization of the chiral biomolecule-COF 3D-printed constructure was performed by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and energy-dispersive Xray spectroscopy (EDX). A tryptophan (Trp) enantiomer was chosen as the model chiral molecule to estimate the chiral recognition ability of the magnetic COF and BSA-based 3DE (Fe3O4@COF@BSA/3DE). We have demonstrated that the Fe3O4@COF@BSA/3DE exhibited excellent chiral recognition to L-Trp as compared to D-Trp. The chiral protein-COF sensing interface was used to determine the concentration of L-Trp in a racemic mixture of D-Trp and L-Trp. This strategy of on-demand fabrication of 3D-printed protein-COF-modified electrodes opens up new approaches for enantiomer recognition.
Klíčová slova
3D printing technology, electrochemical sensor devices, scanning electron microscopy
Autoři
WANG, L.; GAO, W.; NG, S.; PUMERA, M.
Vydáno
30. 3. 2021
Nakladatel
AMER CHEMICAL SOC
Místo
WASHINGTON
ISSN
1520-6882
Periodikum
Analytical Chemistry
Ročník
93
Číslo
12
Stát
Spojené státy americké
Strany od
5277
Strany do
5283
Strany počet
7
URL
https://pubs.acs.org/doi/10.1021/acs.analchem.1c00322
BibTex
@article{BUT171824, author="Lujun {Wang} and Wanli {Gao} and Siow Woon {Ng} and Martin {Pumera}", title="Chiral Protein-Covalent Organic Framework 3D-Printed Structures as Chiral Biosensors", journal="Analytical Chemistry", year="2021", volume="93", number="12", pages="5277--5283", doi="10.1021/acs.analchem.1c00322", issn="1520-6882", url="https://pubs.acs.org/doi/10.1021/acs.analchem.1c00322" }