Detail publikace

Micellar electrokinetic chromatography as a powerful analytical tool for research on prebiotic chemistry

ZEMÁNKOVÁ, K. NEJDL, L. BEZDĚKOVÁ, J. VODOVÁ, M. PETERA, L. PASTOREK, A. CIVIŠ, S. KUBELÍK, P. FERUS, M. ADAM, V. VACULOVIČOVÁ, M.

Originální název

Micellar electrokinetic chromatography as a powerful analytical tool for research on prebiotic chemistry

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Capillary electromigration techniques have proven their capabilities in detection of variety of analytes from inorganic ions and small organic molecules through bio(macro)molecules to large analytes such as cells or nano/ micro particles. Also broad range of potential applications includes food and environmental analysis, biomedical and pharmaceutical investigations or even diagnostics. In this work, it was demonstrated that capillary micellar electrokinetic chromatography is an excellent tool extremely helpful in investigations focused on prebiotic synthesis of molecules essential for formation of life on early Earth & ndash; nucleobases. In particular, rapid separation of nucleobases (< 2 min) was achieved in 40 mM borate buffer separation electrolyte containing 60 mM sodium dodecyl sulfate as an additive. This approach enabled detection of nucleobases formed in thermolysed formamide under conditions simulating the environment occurring on early Earth. Moreover, polydopamine-based molecularly imprinted polymers specific to thymine and uracil improved detection of these low abundant products

Klíčová slova

Capillary electrophoresis; Purine; Pyrimidine; Nucleobases; Origin of life; Molecularly imprinted polymers

Autoři

ZEMÁNKOVÁ, K.; NEJDL, L.; BEZDĚKOVÁ, J.; VODOVÁ, M.; PETERA, L.; PASTOREK, A.; CIVIŠ, S.; KUBELÍK, P.; FERUS, M.; ADAM, V.; VACULOVIČOVÁ, M.

Vydáno

1. 8. 2021

ISSN

0026-265X

Periodikum

MICROCHEMICAL JOURNAL

Ročník

167

Číslo

106022

Stát

Nizozemsko

Strany od

1

Strany do

7

Strany počet

7

URL

https://doi.org/10.1016/j.microc.2021.106022

BibTex

@article{BUT171936,
  author="Kristýna {Zemánková} and Lukáš {Nejdl} and Jaroslava {Bezděková} and Milada {Vodová} and Lukáš {Petera} and Adam {Pastorek} and Svatopluk {Civiš} and Petr {Kubelík} and Martin {Ferus} and Vojtěch {Adam} and Markéta {Vaculovičová}",
  title="Micellar electrokinetic chromatography as a powerful analytical tool for research on prebiotic chemistry",
  journal="MICROCHEMICAL JOURNAL",
  year="2021",
  volume="167",
  number="106022",
  pages="1--7",
  doi="10.1016/j.microc.2021.106022",
  issn="0026-265X",
  url="https://doi.org/10.1016/j.microc.2021.106022"
}