Detail publikace

The Anti-Proliferative Activity of Coordination Compound-Based ZnO Nanoparticles as a Promising Agent Against Triple Negative Breast Cancer Cells

ŠTĚPÁNKOVÁ, H. SWIATKOWSKI, M. KRUSZYŃSKI, R. ŠVEC, P. MICHÁLKOVÁ, H. SMOLÍKOVÁ, V. RIDOŠKOVÁ, A. ŠPLÍCHAL, Z. MICHÁLEK, P. RICHTERA, L. KOPEL, P. ADAM, V. HEGER, Z. REX, S.

Originální název

The Anti-Proliferative Activity of Coordination Compound-Based ZnO Nanoparticles as a Promising Agent Against Triple Negative Breast Cancer Cells

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Purpose: The present study deals with the in vitro evaluation of the potential use of coordination compound-based zinc oxide (ZnO) nanoparticles (NPs) for the treatment of triple negative breast cancer cells (TNBrCa). As BrCa is one of the most prevalent cancer types and TNBrCa treatment is difficult due to poor prognosis and a high metastasis rate, finding a more reliable treatment option should be of the utmost interest. Methods: Prepared by reacting zinc carboxylates (formate, acetate, propionate, butyrate, isobutyrate, valerate) and hexamethylenetetramine, 4 distinct coordination compounds were further subjected to two modes of conversion into ZnO NPs - ultrasonication with oleic acid or heating of pure precursors in an air atmosphere. After detailed characterization, the resulting ZnO NPs were subjected to in vitro testing of cytotoxicity toward TNBrCa and normal breast epithelial cells. Further, their biocompatibility was evaluated. Results: The resulting ZnO NPs provide distinct morphological features, size, biocompatibility, and selective cytotoxicity toward TNBrCa cells. They internalize into two types of TNBrCa cells and imbalance their redox homeostasis, influencing their metabolism, morphology, and ultimately leading to their death via apoptosis or necrosis. Conclusion: The crucial properties of ZnO NPs seem to be their morphology, size, and zinc content. The ZnO NPs with the most preferential values of all three properties show great promise for a future potential use in the therapy of TNBrCa.

Klíčová slova

carboxylate, hexamethylenetetramine, nanoparticles, redox homeostasis imbalance, triple negative breast cancer, zinc oxide coordination compounds

Autoři

ŠTĚPÁNKOVÁ, H.; SWIATKOWSKI, M.; KRUSZYŃSKI, R.; ŠVEC, P.; MICHÁLKOVÁ, H.; SMOLÍKOVÁ, V.; RIDOŠKOVÁ, A.; ŠPLÍCHAL, Z.; MICHÁLEK, P.; RICHTERA, L.; KOPEL, P.; ADAM, V.; HEGER, Z.; REX, S.

Vydáno

12. 7. 2021

Nakladatel

Dove Press

ISSN

1178-2013

Periodikum

International Journal of Nanomedicine

Ročník

16

Číslo

1

Stát

Nový Zéland

Strany od

4431

Strany do

4449

Strany počet

19

URL

https://www.dovepress.com/the-anti-proliferative-activity-of-coordination-compound-based-zno-nan-peer-reviewed-fulltext-article-IJN

Plný text v Digitální knihovně

http://hdl.handle.net/11012/200950

BibTex

@article{BUT171965,
  author="Hana {Štěpánková} and Marcin {Swiatkowski} and Rafał {Kruszyński} and Pavel {Švec} and Hana {Michálková} and Vendula {Smolíková} and Andrea {Ridošková} and Zbyněk {Šplíchal} and Petr {Michálek} and Lukáš {Richtera} and Pavel {Kopel} and Vojtěch {Adam} and Zbyněk {Heger} and Simona {Rex}",
  title="The Anti-Proliferative Activity of Coordination Compound-Based ZnO Nanoparticles as a Promising Agent Against Triple Negative Breast Cancer Cells",
  journal="International Journal of Nanomedicine",
  year="2021",
  volume="16",
  number="1",
  pages="4431--4449",
  doi="10.2147/IJN.S304902",
  issn="1178-2013",
  url="https://www.dovepress.com/the-anti-proliferative-activity-of-coordination-compound-based-zno-nan-peer-reviewed-fulltext-article-IJN"
}