Přístupnostní navigace
E-přihláška
Vyhledávání Vyhledat Zavřít
Detail publikace
JUGAS, R. SEDLÁŘ, K. VÍTEK, M. NYKRÝNOVÁ, M. BARTOŇ, V. BEZDÍČEK, M. LENGEROVÁ, M. ŠKUTKOVÁ, H.
Originální název
CNproScan: Hybrid CNV detection for bacterial genomes
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Discovering copy number variation (CNV) in bacteria is not in the spotlight compared to the attention focused on CNV detection in eukaryotes. However, challenges arising from bacterial drug resistance bring further interest to the topic of CNV and its role in drug resistance. General CNV detection methods do not consider bacteria's features and there is space to improve detection accuracy. Here, we present a CNV detection method called CNproScan focused on bacterial genomes. CNproScan implements a hybrid approach and other bacteria-focused features and depends only on NGS data. We benchmarked our method and compared it to the previously published methods and we can resolve to achieve a higher detection rate together with providing other beneficial features, such as CNV classification. Compared with other methods, CNproScan can detect much shorter CNV events.
Klíčová slova
Next-generation sequencing; Copy number variation; Bacteria; Drug resistance
Autoři
JUGAS, R.; SEDLÁŘ, K.; VÍTEK, M.; NYKRÝNOVÁ, M.; BARTOŇ, V.; BEZDÍČEK, M.; LENGEROVÁ, M.; ŠKUTKOVÁ, H.
Vydáno
3. 7. 2021
Nakladatel
Elsevier
ISSN
0888-7543
Periodikum
GENOMICS
Ročník
113
Číslo
5
Stát
Spojené státy americké
Strany od
3103
Strany do
3111
Strany počet
9
URL
https://www.sciencedirect.com/science/article/abs/pii/S0888754321002779
BibTex
@article{BUT172131, author="Robin {Jugas} and Karel {Sedlář} and Martin {Vítek} and Markéta {Jakubíčková} and Vojtěch {Bartoň} and Matěj {Bezdíček} and Martina {Lengerová} and Helena {Vítková}", title="CNproScan: Hybrid CNV detection for bacterial genomes ", journal="GENOMICS", year="2021", volume="113", number="5", pages="3103--3111", doi="10.1016/j.ygeno.2021.06.040", issn="0888-7543", url="https://www.sciencedirect.com/science/article/abs/pii/S0888754321002779" }