Detail publikace

Hepatocyte and immune cell crosstalk in non-alcoholic fatty liver disease

CARRANZA-TREJO, A. M. VĚTVIČKA, V. VIŠTEJNOVÁ, L. KRÁLÍČKOVÁ, M. MONTUFAR JIMENEZ, E.

Originální název

Hepatocyte and immune cell crosstalk in non-alcoholic fatty liver disease

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Introduction: Nonalcoholic fatty liver disease (NAFLD) is the most widespread chronic liver disease in the world. It can evolve into nonalcoholic steatohepatitis (NASH) where inflammation and hepatocyte ballooning are key participants in the determination of this steatotic state. Areas covered: To provide a systematic overview and current understanding of the role of inflammation in NAFLD and its progression to NASH, the function of the cells involved, and the activation pathways of the innate immunity and cell death; resulting in inflammation and chronic liver disease. A PubMed search was made with relevant articles together with relevant references were included for the writing of this review. Expert opinion: Innate and adaptive immunity are the key players in the NAFLD progression; some of the markers presented during NAFLD are also known to be immunity biomarkers. All cells involved in NAFLD and NASH are known to have immunoregulatory properties and their imbalance will completely change the cytokine profile and form a pro-inflammatory microenvironment. It is necessary to fully answer the question of what initiators and metabolic imbalances are particularly important, considering sterile inflammation as the architect of the disease. Due to the shortage of elucidation of NASH progression, we discuss in this review, how inflammation is a key part of this development and we presume the targets should lead to inflammation and oxidative stress treatment.

Klíčová slova

Fat; immune system; liver; inflammation; nonalcoholic fatty liver disease; obesity; steatosis; sterile inflammation

Autoři

CARRANZA-TREJO, A. M.; VĚTVIČKA, V.; VIŠTEJNOVÁ, L.; KRÁLÍČKOVÁ, M.; MONTUFAR JIMENEZ, E.

Vydáno

18. 2. 2021

Nakladatel

TAYLOR & FRANCIS LTD

Místo

ABINGDON

ISSN

1747-4124

Periodikum

Expert Review of Gastroenterology and Hepatology

Ročník

15

Číslo

7

Stát

Spojené království Velké Británie a Severního Irska

Strany od

783

Strany do

796

Strany počet

14

URL

http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=E1oMPEVLfPjUnl93sLi&page=1&doc=1

BibTex

@article{BUT172218,
  author="CARRANZA-TREJO, A. M. and VĚTVIČKA, V. and VIŠTEJNOVÁ, L. and KRÁLÍČKOVÁ, M. and MONTUFAR JIMENEZ, E.",
  title="Hepatocyte and immune cell crosstalk in non-alcoholic fatty liver disease",
  journal="Expert Review of Gastroenterology and Hepatology",
  year="2021",
  volume="15",
  number="7",
  pages="783--796",
  doi="10.1080/17474124.2021.1887730",
  issn="1747-4124",
  url="http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=E1oMPEVLfPjUnl93sLi&page=1&doc=1"
}