Přístupnostní navigace
E-přihláška
Vyhledávání Vyhledat Zavřít
Detail publikace
JAKKA, V. BURŠA, J.
Originální název
Impact of physiological loads of arterial wall on nucleus deformation in endothelial cells: A computational study
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Introduction: Computational modeling can enhance the understanding of cell mechanics. To achieve this, finite element models of endothelial cells were proposed with shapes mimicking their natural state inside the endothelium within the cardiovascular system. Implementing the recently proposed bendo-tensegrity concept, these models consider flexural (buckling) as well as tensional/compressional behavior of microtubules and also incorporate the waviness of intermediate filaments. Materials and methods: Four different models were created (flat and domed hexagons, both regular and elongated in the direction of blood flow) and loaded by biaxial deformation, blood pressure, and shear load from blood flow - natural physiological conditions of the arterial endothelium - aiming to investigate the "in situ" mechanical response of the cell. Results: The impact of individual components of loads on the nucleus deformation (more specifically on the first principal strain) potentially influencing mechanotransduction was investigated and the role of the cytoskeleton and its constituents in the mechanical response of the endothelial cell was assessed. The results show (i) the impact of pulsating blood pressure on cyclic deformations of the nucleus, which increase substantially with decreasing axial pre-stretch of the cell, (ii) the importance of relatively low shear stresses in the cell response and nucleus deformation. Conclusion: Not only the pulsatile blood pressure but also the wall shear stress may induce significant deformation of the nucleus and thus trigger remodelation processes in endothelial cells.
Klíčová slova
Cell mechanics; Biaxial load; Finite element model; Bendo-tensegrity; Shear load
Autoři
JAKKA, V.; BURŠA, J.
Vydáno
24. 1. 2022
Nakladatel
PERGAMON-ELSEVIER SCIENCE LTD
Místo
OXFORD
ISSN
0010-4825
Periodikum
COMPUTERS IN BIOLOGY AND MEDICINE
Ročník
143
Číslo
Stát
Spojené státy americké
Strany od
105266-1
Strany do
105266-11
Strany počet
11
URL
https://www.sciencedirect.com/science/article/pii/S0010482522000580