Detail publikace

3D-Printed COVID-19 immunosensors with electronic readout

MUÑOZ MARTIN, J. PUMERA, M.

Originální název

3D-Printed COVID-19 immunosensors with electronic readout

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

3D printing technology has brought light in the fight against the COVID-19 global pandemic event through the decentralized and on-demand manufacture of different personal protective equipment and medical devices. Nonetheless, since this technology is still in an early stage, the use of 3D-printed electronic devices for antigen test developments is almost an unexplored field. Herein, a robust and general bottom-up biofunctionalization approach via surface engineering is reported aiming at providing the bases for the fabrication of the first 3D-printed COVID-19 immunosensor prototype with electronic readout. The 3D-printed COVID-19 immunosensor was constructed by covalently anchoring the COVID-19 recombinant protein on a 3D-printed graphene-based nanocomposite electrode surface. The electrical readout relies on impedimetrically monitoring changes at the electrode/electrolyte interface after interacting with the monoclonal COVID-19 antibody via competitive assay, fact that hinders the redox conversion of a benchmark redox marker. Overall, the developed 3D-printed system exhibits promising electroanalytical capabilities in both buffered and human serum samples, displaying an excellent linear response with a detection limit at trace levels (0.5 +/- 0.1 mu g.mL(-1)). Such achievements demonstrate advantage of light-of-speed distribution of 3D printing datafiles with localized point-of-care low-cost printing and bioelectronic devices to help contain the spread of emerging infectious diseases such as COVID-19. This technology is applicable to any post-COVID-19 SARS diseases.

Klíčová slova

3D-printed electrodes; SARS-CoV-2; Antigen test; Electrochemical detection; Surface engineering

Autoři

MUÑOZ MARTIN, J.; PUMERA, M.

Vydáno

1. 12. 2021

Nakladatel

ELSEVIER SCIENCE SA

Místo

LAUSANNE

ISSN

1873-3212

Periodikum

CHEMICAL ENGINEERING JOURNAL

Ročník

425

Číslo

1

Stát

Švýcarská konfederace

Strany od

131433-1

Strany do

131433-2

Strany počet

8

URL