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MUÑOZ MARTIN, J. PUMERA, M.
Originální název
3D-Printed COVID-19 immunosensors with electronic readout
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
3D printing technology has brought light in the fight against the COVID-19 global pandemic event through the decentralized and on-demand manufacture of different personal protective equipment and medical devices. Nonetheless, since this technology is still in an early stage, the use of 3D-printed electronic devices for antigen test developments is almost an unexplored field. Herein, a robust and general bottom-up biofunctionalization approach via surface engineering is reported aiming at providing the bases for the fabrication of the first 3D-printed COVID-19 immunosensor prototype with electronic readout. The 3D-printed COVID-19 immunosensor was constructed by covalently anchoring the COVID-19 recombinant protein on a 3D-printed graphene-based nanocomposite electrode surface. The electrical readout relies on impedimetrically monitoring changes at the electrode/electrolyte interface after interacting with the monoclonal COVID-19 antibody via competitive assay, fact that hinders the redox conversion of a benchmark redox marker. Overall, the developed 3D-printed system exhibits promising electroanalytical capabilities in both buffered and human serum samples, displaying an excellent linear response with a detection limit at trace levels (0.5 +/- 0.1 mu g.mL(-1)). Such achievements demonstrate advantage of light-of-speed distribution of 3D printing datafiles with localized point-of-care low-cost printing and bioelectronic devices to help contain the spread of emerging infectious diseases such as COVID-19. This technology is applicable to any post-COVID-19 SARS diseases.
Klíčová slova
3D-printed electrodes; SARS-CoV-2; Antigen test; Electrochemical detection; Surface engineering
Autoři
MUÑOZ MARTIN, J.; PUMERA, M.
Vydáno
1. 12. 2021
Nakladatel
ELSEVIER SCIENCE SA
Místo
LAUSANNE
ISSN
1873-3212
Periodikum
CHEMICAL ENGINEERING JOURNAL
Ročník
425
Číslo
1
Stát
Švýcarská konfederace
Strany od
131433-1
Strany do
131433-2
Strany počet
8
URL
https://www.sciencedirect.com/science/article/pii/S138589472103014X?via%3Dihub