Lung simulation – an alternative approach to animal testing for applications in aerosol and respiratory research

abstrakt

angličtina

Current developments in legal provisions and humane experimental procedures have shown the necessity of increasing the number of opportunities for alternatives to animal testing procedures. This topic especially seems challenging when a generic environmental factor, like ubiquitous aerosols, are taken into account. Approaches in aerosol and respiratory research, allowing conclusions on deposition and actually inhaled and exhaled particle number concentrations, have to be developed into this area as well. The xPULM simulator shall close the gap from already existing and well established procedures and experimental setups from the field of numerical simulation, over mechanical simulation approaches to in vitro procedures. All of the named test methodologies allow very specific and comprehensive research on effects of aerosol inhalation, but lack information on an organ scale level. The active breathing lung simulator xPULM, aims to bridge this gap by allowing multiple lung equivalents, like latex bags and primed porcine lungs (salvaged from the meat production process), to breath under different physiological and pathological breathing patterns, taking up surrounding particles which can be analysed in terms of their number concentration and size distribution.

lung simulation, breathing simulation

FORJAN, M.; PAŠTĚKA, R.; DRAUSCHKE, A.

26. 9. 2018

2194-0479

ALTEX proceedings

7

2

Švýcarská konfederace

1

https://proceedings.altex.org/data/2018-02/Linz-2018_webversion_a.pdf