Detail publikace

Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa (vol 72, pg 1437, 2018)

KYNICKÝ, J. MILOSAVLJEVIĆ, V. JELÍNKOVÁ, P. HADDAD, Y. MERLOS RODRIGO, M. MICHÁLKOVÁ, H. BYTEŠNÍKOVÁ, Z. BRTNICKÝ, M. RICHTERA, L. KOPEL, P. ADAM, V.

Originální název

Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa (vol 72, pg 1437, 2018)

Typ

různé

Jazyk

angličtina

Originální abstrakt

Eu(III) and Tb(III) Schiff base complexes are applicable in various fields such as sensing, assays, screening protocols in vitro, and imaging studies in vitro or in vivo. Fluorescent europium and terbium complexes and their interaction with cell penetrating peptide (KKKRKC) can represent an excellent key for understanding pathway of peptide transportation though cell membrane and the application of Schiff base complexes as potential antibacterial drugs. The Schiff base-metal complexes and its conjugates with peptide were tested for their antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium. Schiff base-metal complexes conjugated with peptide show minor toxicity in normal human PNT1A cells and high antibacterial activity against P. aeruginosa and S. typhimurium, where IC50 down to 125.9 and/or 36.1 A mu M were found for P. aeruginosa and S. typhimurium, respectively. Our results strongly suggest that Schiff base-metal complexes conjugated with peptide have great potential to be developed into highly effective antibacterial drug.

Klíčová slova

Schiff base; Europium; Terbium; Cell penetrating peptide; Antimicrobial agents

Autoři

KYNICKÝ, J.; MILOSAVLJEVIĆ, V.; JELÍNKOVÁ, P.; HADDAD, Y.; MERLOS RODRIGO, M.; MICHÁLKOVÁ, H.; BYTEŠNÍKOVÁ, Z.; BRTNICKÝ, M.; RICHTERA, L.; KOPEL, P.; ADAM, V.

Vydáno

28. 2. 2022

Strany od

1269

Strany do

1270

Strany počet

2

BibTex

@misc{BUT177288,
  author="Jindřich {Kynický} and Vedran {Milosavljević} and Pavlína {Jelínková} and Yazan Abdulmajeed Eyadh {Haddad} and Miguel Ángel {Merlos Rodrigo} and Hana {Michálková} and Zuzana {Bytešníková} and Martin {Brtnický} and Lukáš {Richtera} and Pavel {Kopel} and Vojtěch {Adam}",
  title="Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa (vol 72, pg 1437, 2018)",
  year="2022",
  pages="1269--1270",
  doi="10.1007/s11696-021-01998-w",
  note="miscellaneous"
}